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急性心肌梗死患者应用尿激酶早期溶栓治疗临床体会
急性心肌梗死患者应用尿激酶早期溶栓治疗临床体会
[摘要] 目的 探讨基层医院应用尿激酶溶栓治疗急性心肌梗死的临床疗效。 方法 选择2005年2月~2010年12月收治的AMI患者31例,均应用尿激酶进行早期溶栓治疗。 结果 本组再通率为70.9%(22/31),发病后溶栓时间愈早再通率愈高;患者胸痛症状、血清心肌酶谱及心电图等指标明显改善。 结论 尿激酶溶栓治疗急性心肌梗死安全、有效,尤其适用于基层医院的救治。
[关键词] 急性心肌梗死;静脉溶栓;尿激酶;治疗
[中图分类号] R542.2+2 [文献标识码] A [文章编号] 1674-4721(2012)02(a)-0024-02
The clinical experience of early intravenous thrombolysis with urokinase on acute myocardial infrarction in the primary hospital
LIANG Hanlin
Department of Internal Medicine, the Traditional Chinese Medicine Hospital of Luocheng Mulam Nationality in Guangxi Zhuang Autonomous Region, Luocheng 546400, China
[Abstract] Objective To investigate the clinical effect of urokinase for treating acute myocardial infarction. Methods Chose 31 patients with AMI from February 2005 to December 2010 in our hospital, who were treated with early intravenous thrombolysis with urokinase. Results The total recanalization rate was 70.9%(22/31), the earlier time of incidence to the beginning of thrombolysis, and then the higher rate of recanalization. The clinical indicators such as chest pain sympotoms,serum myocardial enzymes and ECG were significantly improved. Conclusion It is safe and effective that early intravenous thrombolysis with urokinase in acute myocardial infarction, and especially apply for trratment in the primary hospital.
[Key words] Acute myocardial infrarction; Intravenous thrombolysis; Urokinase; Treatment
急性心肌梗死(acute myocardio infarction,AMI)是在冠脉硬化基础上导致血管腔闭塞、血流急剧下降或中断而引起的急性心肌缺血性坏死,是临床常见的心血管急症之一。冠脉介入(PCI)手术在多数基层医院无法开展,而静脉溶栓以其操作简便、有效等特点成为重要措施[1],该方法可使闭塞冠脉再通而恢复缺血区灌注,对挽救濒死心肌、减少梗死面积及改善心功能具有重要意义。近几年笔者对31例AMI患者应用尿激酶(UK)静脉溶栓治疗,取得满意效果,现报道如下:
1 资??与方法
1.1 一般资料
选择2005年2月~2010年12月本科收治的31例AMI患者,男20例,女11例,年龄35~78岁,平均59.5岁。梗死部位:广泛前壁10例,前壁6例,前间壁5例,下壁9例,高侧壁1例。全部患者诊断均符合WHO关于AMI的诊断标准[2]。并具备下述条件[3]:胸部疼痛持续30 min以上,且含服硝酸甘油症状不缓解;心电图相邻两个或两个以上导联ST段抬高,在肢体导联> 0.1 mV,胸导联> 0.2 mV;首次AMI发病≤6 h,年龄≤70岁,体质较好者可适当放宽;均无溶栓禁忌证,并经患者或家属签字同意UK静脉溶栓治疗。
1.2 方法
溶栓前常规做12导
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