戒烟对慢性阻塞性肺疾病患者肺功能影响.docVIP

戒烟对慢性阻塞性肺疾病患者肺功能影响 　　文章编号：1005-619X（2008）09-0524-03 　　【摘 要】 目的 研究烟龄（年）、烟量（年支）、戒烟时间（年）与慢性阻塞性肺疾病(COPD)患者肺通气功能指标[FEV1%、FEV1/FVC(%)、PEF%、FEF25%、 FEF50%、MMEF%]的关系。方法 测定156例稳定期COPD患者的肺功能[FEV1%、FEV1/FVC(%)、PEF%、FEF25%、 FEF50%、MMEF%]，根据气道阻塞程度分为ⅡA、ⅡB、Ⅲ级COPD。结果 各组间的PEF%、FEF25%、 FEF50%、MMEF%等肺通气功能指标的比较差异均有统计学意义(P1%、FEV1/FVC(%)、 FEF25%、 FEF50%、MMEF%等肺通气功能指标与烟量及烟龄存在负相关，与戒烟时间存在正相关；在控制年龄、烟量等因素后，FEV1%、FEV1/FVC(%)、FEF25%、 FEF50%、MMEF%等肺通气功能的指标与戒烟时间存在正相关，而与烟龄存在负相关。结论 戒烟可减缓COPD患者肺功能的恶化。 　　【关键词】 肺疾病；阻塞性；肺功能；吸烟 　　【Abstract】 Objective To investigate whether smoking cessation ameliorates the changes in pulmonary function of the patients with chronic obstructive pulmonary disease(COPD). Methods Spirometry measurements including forced expiratory volume in one second(FEV1), forced vital capacity(FVC),peak expiratory flow(PEF), maximal expiratory flow in 75% vital capacity(FEF25), maximal expiratory flow in 50% vital capacity(FEF50), maximal mid-expiratory flow(MMEF) were undertaken in 156 patients with COPD, who were divided into three groups according to their FEV1% (the predicted FEV1 percentage): the moderate A group, the moderate B group and severe group. Results The comparisons on FEV1% predicted, FEV1/FVC(%), PEF% predicted, FEF25% predicted, FEF50% predicted, MMEF% predicted between the three groups were respectively significant(P1/FVC(%),FEF25% predicted, FEF50% predicted,MMEF% predicted] and the years of smoking cessation. After adjusting for the age and the pack-years index, there were positive relationship with FEV1%,FEV1/FVC(%),FEF25%,FEF50%,MMEF% to the years of smoking cessation(P1%, FEV1/FVC(%),FEF25%,FEF50% and MMEF% to the years of smoking.Conclusion Smoking cessation ameliorates deterioration of COPD. 　　【Key words】 Pulmonary disease;Obstructive;Pulmonary function;Cigarette smoking 　　 　　慢性阻塞性肺疾病(COPD)是一种主要的慢性致残和致死性疾病，近年来全球的患病人数在不断增加[1]。我国城市呼吸系统疾病（主要???COPD）是导致死亡的第四位的疾病，在农村则排第一位，COPD是一种严重影响人们身体健康的疾病[2]。吸烟是引起COPD的最主要危险因素，而戒烟能缓解COPD患者肺功能恶化的程度。本研究主要观察COPD患者的烟龄（年）、烟量（年支）