肥胖 血脂与中老年人轻度认知障碍的关联研究-association study of obesity and blood lipid with mild cognitive impairment in middle-aged and elderly people.docxVIP

脂蛋白胆固醇的上升而增加，而且也随血清总胆固醇及低密度脂蛋白胆固醇的升高而增加( P0. 01) ；[ 0]（3）多元线性回归分析在调整了年龄、教育、吸烟状况、喝酒状况、体力 活动、空腹血糖、总胆固醇、甘油三酯、高密度脂蛋白、收缩压和舒张压等因素 后，在男女性显示腰臀比、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固 醇对 10 个单词延迟记忆得分有影响；（4）当以 10 个单词延迟记忆得分≤3 分作为有无轻度认知功能受损进行 Logistic 回归分析，经单因素分析及多因素多模型调整后，随着腰臀比的增大在 女性患轻度认知功能受损的危险性明显增加，趋势检验 (P0.01)，当腰臀比偏高 时， 女性 OR 及 95%CI 为 1.15(1.03-1.27)，男性为 1.22(1.04-1.44)；随着高密度 脂蛋白胆固醇的升高，女性患轻度认知功能受损的危险性明显下降，趋势检验 (P0.01)。结论：中心性肥胖与认知功能受损有关联，以腰臀比评价认知功能比其他肥 胖测量指标更敏感，高密度脂蛋白胆固醇下降是女性患认知功能受损的危险因 素。关键词：肥胖，血脂，轻度认知受损，体重指数，腰臀比，腰高比，腰围， 高密度脂蛋白胆固醇The association between adiposity, serum lipid profile and mild cognition impairment in middle and elderly populationABSTRACTObjective: Obesity is a public health problem of increasing prevalence worldwide. It had been confirmed to cause chronic cordis and cerebral vessels disease. Recent study had also indicated the association between obesity or dyslipidemia and Alzheimers disease. However, it remains undetermined whether the adiposity and serum lipid profile are also associated with early mild cognition impairment in asymptomatic individuals. We aimed to explore the relations of anthropometric indices of adiposity and serum lipid concentration with middle and elderly population in Guangzhou Biobank Cohort Study and Search for the sensitive biomarker that influence cognitive function. So that to provide the scientific basis for screening mild cognitive impairment(MCI) population and prevention and control dementia.Methods: 19181 subjects aged 50 to 85 years were included in this study from the first and second recruitment phase of the Guangzhou Biobank Cohort Study. The subjects received a face-to-face interviews to collect detailed information on their sociodemographic background, occupational exposures, living environment, lifestyle, family and personal disease histories, and had a physical examination and tests including 12-lead ECG, chest radiograph, and pulmonary function testing. Each subject was tested for a range of fasting biochemical parameters. Th