血清和腹腔液中ca125 tnfα与子宫内膜异位症患者的相关性分析-correlation analysis of ca 125 tnf α in serum and peritoneal fluid with endometriosis patients.docxVIP
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血清和腹腔液中ca125 tnfα与子宫内膜异位症患者的相关性分析-correlation analysis of ca 125 tnf α in serum and peritoneal fluid with endometriosis patients
中英文缩略词对照表白介素-6IL-6interleukin-6表皮生长因子(EGF)epidermalgrowthfactor单核细胞趋化蛋白-1(MCP-1)monocytechemotacticprotein-1二噁英dioxin芳烃受体AhRaromatichydrocarbonreceptor芳香化酶(P450arom)aromatizingenzyme核转录因子(NfkB)nuclearfactorkappa前列腺素(PGs)prostaglandins糖类抗原-125(CA125)carbohydrateantigen125微血管密度(MVD)microvasculardensity血管内皮生长因子(VEGF)vascularendothelialgrowthfactor子宫内膜抗体(EMAb)endometrialantibody肿瘤坏死因子α(TNFα)tumornecrosisfactor-alpha转化生长因子β(TGF-β)transforminggrowthfactor-β组织因子(TF)tissuefactor血清和腹腔液中CA125、TNFα与子宫内膜异位症的相关性研究中文摘要目的:探讨子宫内膜异位症(EMS)患者血清和腹腔液中CA125、TNFα水平的变化及其与内异症的相关性。方法:把52例内异症患者(内异症组)按r-AFS评分法(美国生育协会修订的腹腔镜诊断内异症的评分系统)分为I一Ⅳ期,其中I、Ⅱ期为I组共21例,Ⅲ、Ⅳ期为II组共31例,子宫肌瘤患者(对照组)共52例,采用ELISA方法(酶联免疫吸附双抗体夹心法)来检测血清及腹腔液中TNFα的含量,采用蛋白芯片法来检测血清及腹腔液中CA125的水平。结果:(1)内异症组患者血清中CA125浓度为(39.19±15.24)U/ml、TNFα的浓度为(26.96±11.20)pg/ml,对照组患者血清中CA125浓度为(25.54±9.76)U/ml、TNFα的浓度为(11.94±5.28)pg/ml,内异症组患者血清中CA125、TNFα浓度明显高于对照组患者血清中CA125、TNFα浓度,比较有统计学意义(P0.05);(2)I组(I-II期)患者血清中CA125的浓度为(40.43±15.96)U/ml、TNFα的浓度为(24.85±13.85)pg/ml,II组(III-IV期)患者血清中CA125的浓度为(38.29±15.32)U/ml、TNFα的浓度为(28.40±8.96)pg/ml,两组患者血清中CA125、TNFα比较均无统计学意义(P0.05);(3)内异症组患者腹腔液中CA125浓度为(326.11±121.00)U/ml、TNFα的浓度为(47.50±20.40)pg/ml,对照组患者腹腔液中CA125浓度为(153.45±61.30)U/ml、TNFα的浓度为(20.06±9.84)pg/ml,内异症组患者腹腔液中CA125、TNFα浓度明显高于对照组患者腹腔液中CA125、TNFα的浓度,比较有统计学意义(P0.05);(4)I组(I-II期)患者腹腔液中CA125浓度为(316.66±134.06)U/ml、TNFα的浓度为(41.44±21.23)pg/ml,II组(III-IV期)患者腹腔液中CA125浓度为(392.89±102.40)U/ml、TNFα的浓度为(53.22±20.13)pg/ml,II组患者腹腔液中CA125、TNFα明显高于I组患者腹腔液中CA125、TNFα浓度,两者比较有统计学意义(PO.05);(5)所有内异症患者血清中CA125浓度为(39.19±15.24)U/ml、TNFα的浓度为(26.96±11.20)pg/ml,腹腔液中CA125浓度为(326.11±121.00)U/ml、TNFα的浓度为(47.50±20.40)pg/ml,腹腔液中CA125、TNFα的浓度均明显高于血清中CA125、TNFα的浓度,两者比较有统计学意义(PO.05)。结论:子宫内膜异位症患者血清及腹腔液中CA125、TNFα与疾病密切相关,腹腔液在监测子宫内膜异位症发生发展中可能较血清有更灵敏及可靠的诊断价值。关键词:子宫内膜异位症肿瘤坏死因子αCA125StudyontheCA125、TNFαinpatientswithendometriosisAbstractObjective:ToinvestigatethelevelsofCarbohydrateAntigen125andtumornecrosisfactor-alpha(TNFα)inserumandperitonealfluidofpatientswithendometriosis.Methods:52patientswithendom
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