吡罗昔康镧配合物合成与表征.docVIP

吡罗昔康镧配合物合成与表征 　　摘要：本论文合成了吡罗昔康和稀土金属镧的配合物，通过紫外光谱、红外光谱、元素分析、电导率、差热-热重等方法对其进行了表征，最后确定其组成为La(pir)2C2H5OHCl3?2H2O。 　　关键词：吡罗昔康稀土金属配合物镧 　　 　　Synthesis，characterization of the complexe of piroxicam and lanthanum（La） 　　 　　Abstract：A new rare earth complexe was sythesised by rare earth chloride（LaCl3）and piroxicam in anhydrous ethanol .The chemical composition and structure of the compound were characterized by IR, UV-Vis , elemental analysis, TG-DTA，conductance. The results show that the chemical composition of the complexe is La (pir)2C2H5OH Cl3?2H2O. 　　Keywordspiroxcam , rare earth , complexe , lanthanum 　　 　　 　　一、Introduction 　　Metal complexes containing non-steroidal anti-inflammatory drugs (NSAIDs ) are among those compounds which have received much attention and increasing interest from a medicinal inorganic chemistry viewpoint[1]. Metal complexes of anti-inflammatory drugs can also be potentially active against other diseases such as cancer and bacterial infections. Piroxicam(Pir) is a potent and extensively used non-steroidal anti-inflammatory (NSAIDs), anti-arthritic drug with a long biological half-life. It is known to react as a monodentate ligand through the pyridyl nitrogen towards Pt(II)[2], as a bidentate chelating ligand via the pyridyl nitrogen and the amide oxygen towards Cu(II) and Cd(II) [3]and as a singly deprotonated tridentate ligand through the enolic oxygen,the pyridyl and the amidenitrogen atoms in the Sn(IV) complex [5]. Iron(II), cobalt(II), nickel(II) ,zinc(II) VO2+, MoO22+ ,Mn2+and UO22+ almost certainly behave similarly to cadmium(II) [3,4,5]. 　　二、Experimental 　　1、Materials and measurements 　　Piroxicam was a gift from Taiyuan satellite pharmaceutical Factory in shanxi province. All reagents and solvents were of analytical grade. IR spectra were recorded on NICOLET-380 FI-IR in the wavenumber region 4000-500 cm-1. UV-Vis spectra were recorded on LENG GUANG 760 -CRT DOUBLE BEAM UV-Vis spectrophotometer. The spectra were recorded as