阿卡波糖对糖耐量异常干预研究.docVIP

阿卡波糖对糖耐量异常干预研究 　　【摘要】 目的 观察阿卡波糖对糖耐量异常患者的治疗效果。方法 用随机双盲法比较119例糖耐量异常患者在饮食加运动控制的基础上给予口服阿卡波糖和安慰剂干预治疗，经治疗1年后，检测空腹血糖(FPG)及葡萄糖耐量试验(OGTT)后2 h血糖(2HPG)，总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、胰岛素抵抗指数、空腹胰岛素(FINS)和OGTT后2 h胰岛素(PINS)水平的变化。结果 阿卡波糖组和安慰剂组治疗前糖耐量无差异无统计学意义(P0．05)。安慰剂组糖尿病的发病率为8．8%；阿卡波糖组与安慰剂组相比FPG、 2HPG、TC、TG、LDL 、FINS及PINS均明显下降，糖尿病的发病率为3．3%。结论 阿卡波糖能够降低IGT人群糖尿病的发病率，减轻胰岛素抵抗的同时，可使糖耐量异常明显改善。 　　【关键词】 阿卡波糖；干预；糖耐量异常；血脂 　　 　　Clinical research on Acarbose of interventive treatment of patients with impaired glucose tolerance CHEN Sheng，LONG Mei．fang，LIU Sai．qin，et al.Liuyang Municipal People Hospital of Hunan Provice， Loudi 417000,China 　　【Abstract】 Objective To investigate the therapeutic efficacy of Acarbose on patients with impaired glucose tolerance.Methods While 140 cases of impaired glucose tolerance were controled diet plus exercise for 1 year，the variations of fasting plasma glucose(FPG)，post prandial plasma glucose(2HPG)， 2 hours after oral glucose tolerance test(OGTT)，insulin(PINS)2 hours after fasting insulin and OGTT，insulin resistance levels in two groups were observed with Acarbose or placebo borandomly and double．blinded.Results There was no significant difference of the sugar tolerance between placebo group and Acarbose group in pretherapy(P0．05).An incidence of diabetes of placebo group was 8．1%;compared to placebo group，the FPG， 2 hPG，FINS andPINS， insulin resistance index were obviously decreased in two groups after treatment of Acarbose，while with an incidence of diabetes of4．6%.Conclusion Application of Acarbose in the intervening treatment OfIGT subjects can reduce the incidence of diabetes and improve impaired glucose tolerance，while it can degrade insulin resistance. 　　【Key words】 Acarbose；Intervention；Impaired glucose tolerance；Lipid 　　 　　2型糖尿病从糖耐量正常(NGT)转变为临床糖尿??的发病过程中，都要经过一个糖耐量受损阶段，即糖耐量低减(impaired glucose tolerance，IGT)状态。IGT的患者发展成为DM及合并大血管疾病的危险性较正常糖耐量(NGT)者相比显著增加，糖尿病预防研究(DPP)已经证实了饮食和运动疗法可以预防IGT向2．DM的转化，且经济、简便,但需长期坚持，故一般人很难持久、规范地做好。因此药物干预成为有效干