雷贝拉唑联合左氧氟沙星与阿莫西林治疗消化性溃疡疗效.docVIP

雷贝拉唑联合左氧氟沙星与阿莫西林治疗消化性溃疡疗效 　　【摘要】 目的 评价雷贝拉唑联合左氧氟沙星与阿莫西林治疗消化性溃疡(PU)的疗效。方法 将120例幽门螺杆菌(Hp)阳性的PU患者随机分为对照组及观察组，每组各60例。观察组给予雷贝拉唑10 mg、左氧氟沙星200 mg、阿莫西林1000 mg，均为2次/d口服。对照组给予奥美拉唑20 mg、克拉霉素500 mg、阿莫西林1000 mg，均为2次/d口服。疗程均为2周。停药后4周复查胃镜及Hp检测。结果 观察组总有效率95%，对照组总有效率80%；观察组Hp根除率为90％，对照组为70%。结论 雷贝拉唑联合左氧氟沙星与阿莫西林治疗Hp阳性的PU疗效好，是理想方法之一。? 　　【关键词】 　　雷贝拉唑；左氧氟沙星；阿莫西林；克拉霉素；消化性溃疡；幽门螺杆菌 　　?? 　　The therapeutic effect of triple combined regimen of Rabeprazole and Levofloxacin, Amoxicill therapy for peptic ulcer 　　 　　WANG Zhao?xuan. Department of Digestive,The First Poeople’s Hospital of Jining,Shandong 272111,China 　　? 　　【Abstract】 Objective 　　To evaluate the therapeutic effect of triple therapy of Rabeprazole and Levofloxacin，Amoxicill combined for peptic ulcer.Methods 120 patients with helicobacter pylori(Hp)infection suffered from peptic ulcer were randomly divided into observation groupand control group,60 cases in each group.Observation group were administrated Rabeprazole(10 mg，twice a day)，Levofloxacin(200 mg，twice a day)and Amoxicill (1000 mg，twice a day)for two weeks.Control group were treated with Omeprazole(20 mg，twice a day)，Amoxicillin(500 mg，twice a day)and Clarithromycin(200 mg，twice a day)for two weeks.Four weeks later, the Hp eradication rate and the total effective rate were observed. Results After the treatment the total effective rate of the observation group was 95%, while that of the control group was 80%,the dfferences were statistically significant (P［1］。本研究我们用新三联雷贝拉唑联合左氧氟沙星与阿莫西林治疗幽门螺杆菌(Hp)阳性的消化性溃疡(PU)患者，取得较好疗效。现将结果报告如下。? 　　1 资料与方法? 　　1.1 一般资料 选取自2009年3月至2011年3月我科收治的120例经胃镜检查确诊为PU，且快速尿素酶试验Hp检查均为阳性。不伴有严重的肝、肾、肺等器官动能障碍及全身性慢性疾病、无有关药??过敏史及4周内未使用质子泵抑制剂、受体拮抗剂及抗菌药物；并排除其他消化道疾病［2］。将所有患者随机分为观察组和对照组，每组各60例。治疗组男34例，女26例，年龄16~68岁，平均42.5岁；对照组男29例，女31例，年龄18~64岁，平均44.6岁。两组患者在性别、年龄、病情等方面均经统计学比较差异无统计学意义(P0.05)，具有可比性。? 　　1.2 治疗方法 　　观察组给予雷贝拉唑10 mg、左氧氟沙星200 mg、阿莫西林1000 mg，均为2次/d口服。对照组给予奥美拉唑20 mg、克拉霉素500 mg、阿莫西林1000 mg，均为2次/d口服。疗程均为2周。两组患者在治疗期间禁用其他药物，禁食刺激性食物，治疗前后查肝肾功能、血、尿常规及对Hp检测。停