顺铂联用胸腺肽和艾迪注射液治疗恶性胸腔积液临床观察.docVIP

顺铂联用胸腺肽和艾迪注射液治疗恶性胸腔积液临床观察 　　【摘要】目的：探讨顺铂联用胸腺肽和艾迪注射液在治疗恶性胸腔积液中的疗效。方法：选择我院2003年1月～2007年6月老年内科住院大量恶性胸腔积液患者95例，随机分成试验组和对照组，对照组45例，艾迪注注射液50 ml加入0.9%生理盐水250 ml中，静脉滴注，每天1次15天为1疗程，用顺铂40～60 mg，地塞米松10 mg，利多卡因100 mg，加入0.9%生理盐水40 ml经非流管依次注入胸腔内夹管48小时，缓慢引流，每周1次用1～4次，试验组50例在此基础上胸腔内注入胸腺肽50 mg；观察症状、体征、不良反应、生活质量、血常规、肝肾功、心电图等，治疗结束后6周评定疗效。结果：试验组:完全缓解15例，部分缓解28例，总有效率为86%；对照组:完全缓解9例，部分缓解16例，总有效率为55.5%，P0.05，差异无显著性。结论：顺铂联用胸腺肽和艾迪注射液治疗恶性胸腔积液安全有效，不良反应轻微。 　　【关键词】静脉导管；顺铂；胸腺肽；艾迪注射液；恶性胸腔积液 　　文章编号：1009-5519（2008）01-0009-02 中图分类号：R73 文献标识码：A 　　Clinical observation of cisplatin cimbined with xiongxiantai and aidi injection in m alignant pleural effusion 　　WU Ying，ZHANG Ting，HUANG Si-si，et al. 　　（Department of Internal Medicine，The First Peoples Hospital of Neijiang，Sichuan 641000，China） 　　【Abstract】Objective：To investigate the curative effect of cisplatin combined with xiongxiantai and aidi injection in m alignant pleural effusion. Methods：95 patients with m alignant pleural effusion selected from the geriatrics department of our hospital from November 2003 to June 2007 were divided into experimental group and control group randomly.45 patients in the control group were treated with aidi injection 50 ml in 0.9% normal saline 250 ml by intravenous drip once a day for 15 days,cisplatin 40~60 mg,dexamethoasone 10 mg and lidocaine 100 mg were injected into the thoracic cavity one to four times.Besides those，50 patients in the experimental group were added with xiongxiantai 50 mg by intrathoracic injection.The symptoms，physical signs，adverse reaction,quality of life,blood routine examination，liver function,rend function and ECG were observed，and their clinical effects were evaluated.Results：In the experimental group,the complete remission(CR) was 15 cases，the partial remission(PR) was 28 cases,the total effective rate was 86%；in the control group，CR was 9 cases，PR 16 cases，the total effective rate was 55.5%，with significant difference between two group(P0.05).Conclusion：Cisplatin combined with Xi