脂肪性肝病治疗进展PPT课件.pptVIP

* Development of nonalcoholic hepatic steatosis. Insulin resistance enhances triglyceride (TG) lipolysis and inhibits esterification of free fatty acids (FFA) within adipose tissue. The result is increased serum FFA levels, which are taken up by the liver. Hepatic TG synthesis is driven by the increased influx of FFA and favoured by insulin upregulated lipogenic transcription factors, such as peroxisome proliferator-activated receptor gamma (PPARγ) and sterol regulatory element binding protein (SREBP)-1c. Alternative metabolism of FFA by oxidation is inhibited by insulin. TG export via very-lo