Signal -3-临床五年制2014PPT.pptVIP

EGFR-mediated Ras-MAPK pathway ERK: extracellular signal-regulated kinase(MAPK) MEK: MAPK/ERK kinase(MAPKK) MAPKK P EGF is involved in multiple signal pathways 1.5.2 TPK-associated receptor － JAKs－STAT pathway ● TPK-associated receptor ● JAKs: just another kinases, Janus protein tyrosine kinases ● STAT: signal transducers and activators of transcription(信号传导及 转录激活因子 ) TPK-associated receptor － JAKs－STAT pathway ligand TPK-associated receptor JAKs STAT gene expression P P Nuclear translocation of STAT TPK-associated receptor － JAKs－STAT pathway How to regulate ce