CTHRC1和NFE2L3在结直肠癌组织中表达及相关性.docVIP

CTHRC1和NFE2L3在结直肠癌组织中表达及相关性 　　[摘要] 目的 探讨CTHRC1和NFE2L3在结直肠癌早期诊断的意义。 方法 收集本院2005～2011年经过病理组织学检查诊断结直肠癌的手术标本51例与非癌症的经过病理组织学检查为正常结肠和直肠组织20例，应用免疫组化检测人结直肠中CTHRC1和NFE2L3蛋白的表达情况。 结果 癌组织中CTHRC1表达阳性47例（92.16%），正常组织中阳性1例（5.00%），两组比较差异有统计学意义 （χ2=30.13，P ＜ 0.01）；NFE2L3的瘤组织阳性43例（84.43%），正常组织中6例（30.00%），两组比较差异有统计学意义（χ2=23.22，P ＜ 0.01）。CTHRC1阳性表达组中，NFE2L3的阳性表达率为72.55％（37/51)；在CTHRC1阴性表达组中，NFE2L3阳性表达率为1.96%（1/51），差异有统计学意义（χ2=36.54，r：0.510；P ＜ 0.01），两者表达呈正相关。 结论 CTHRC1是结直肠癌发展过程中的重要因素，而NFE2L3可以直接调节CTHRC1基因的表达，这说明通过抑制NFE2L3的活性可以减少CTHRC1的表达，进而延缓结直肠癌的进展，从而发挥其抗肿瘤的作用。 　　[关键词] 结直肠癌；三螺旋重复胶原蛋白1；核因子（网织红细胞衍生2）样3；癌症生物标记 　　[中图分类号] R735.3 [文献标识码] A [文章编号] 1674-4721（2012）06（a）-0008-02 　　CTHRC1 and NFE2L3 expression in colorectal cancer tissues and correlation 　　CHEN Enbi ZOU Jibin HUANG Yongbo HUANG Wei GAO Xiang LAI Dexin 　　Department of General Surgery, Zhanjiang Center Peoples Hospital in Guangdong Province, Zhanjiang 524023, China 　　[Abstract] Objective To explore the significance of the CTHRC1 and NFE2L3 in the early diagnosis of colorectal cancer. Methods Collected our hospitals 51 cases of colorectal cancers surgical specimens which were diagnosed by the histopathological and 20 cases of non-cancer colorectals normal tissue which were tested by histopathological during 2005 to 2011. Results CTHRC1 expressed positive for 47 cases (92.16%) in cancer tissues, but only 1 case (5.00%) expressed positive in normal tissues, the difference of them was extremely significant (χ2 = 30.13, P ＜ 0.01); the positive of the NFE2L3 which in tumor tissue was in 43 cases (84.43%), but only 6 cases (30.00%) in normal tissue, and the difference was significant too(χ2 = 23.22, P ＜ 0.01). The positive expression rate of the NFE2L3 was 72.55% (37/51) in the CTHRC1s positive expression group; in CTHRC1s negative expression group, NFE2L3 positive expression rate was 1.96% (1/51), the difference was significant (χ2 = 36.54, r : 0.510; P ＜ 0.01), and the two expression was positively correlated. Conclusion In the prog