三氧化二砷粉针剂与水针剂治疗急性早幼粒细胞白血病疗效比较.docVIP

三氧化二砷粉针剂与水针剂治疗急性早幼粒细胞白血病疗效比较 　　[摘要] 目的：探讨三氧化二砷粉针剂与水针剂分别治疗急性早幼粒细胞白血病的疗效，并将两种药物的疗效及不良反应作对比分析。方法：选择沈阳市201医院2008年10月～2010年6月收治的均为初治的急性早幼粒细胞白血病患者38例（粉针剂组）采取三氧化二砷粉针剂治疗，并与我院2003年10月～2008年9月采用三氧化二砷水针剂初治的急性早幼粒细胞白血病患者42例（水针剂组）作对照。记录患者达到完全缓解（CR）的时间、早期DIC出血发生人数、分子遗传学缓解的指标、不良反应等指标。结果：早期DIC出血发生人数、分子遗传学缓解的指标比较，差异均无统计学意义（P＞0.05）。两组患者达到CR的时间比较差异有统计学意义（P＜0.05）。不良反应中除球结膜充血、心电图改变外差异均有统计学意义。结论：三氧化二砷粉针剂治疗急性早幼粒细胞白血病的疗效与三氧化二砷水针剂总体差别不是很大，但达CR时间缩短，不良反应要明显减少，值得在临床推广使用。 　　[关键词] 三氧化二砷；纳维雅；粉针剂；急性早幼粒细胞白血病 　　[中图分类号] R557 [文献标识码] A [文章编号] 1673-7210（2012）01（a）-069-03 　　 　　Efficacy comparison of powder injection and water injection of Arsenic Trioxide in the treatment of acute promyelocytic leukemia 　　LUO Hongshan1, XIAO Junbo1, NIE Yan1, ZHAO Xiaomeng2, SHI Baofu1* 　　1.Department of Hematology, Shenyang 201 Hospital, Liaoning Province, Shenyang 110043, China; 2.Department of Hematology, the First Affiliated Hospital of China Medical University, Liaoning Province, Shenyang 110001, China 　　[Abstract] Objective: To investigate the effects of powder injection and water injection of Arsenic Trioxide in the treatment of acute promyelocytic leukemia and the effects and adverse reactions of the two drugs were compared. Methods: 38 patients with acute promyelocytic leukemia admitted and treated in Shenyang 201 hospital from October 2008 to June 2010 (the powder injection group) were given the powder injection of Arsenic Trioxide, which were compared with the 42 patients with acute promyelocytic leukemia treated with the water injection of Arsenic Trioxide in our hospital from October 2003 to September 2008 (the water injection group). The complete remission (CR) time, the number of people having early disseminated intravascular coagulation (DIC) bleeding, molecular genetics remission indicators, adverse reactions and other indicators were recorded. Results: Comparing the number of people having DIC bleeding and molecular genetics remission indicators, there were no statistically significant differen