法莫替丁脉冲控释的微丸胶囊的制备及其体外释放.doc

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法莫替丁脉冲控释的微丸胶囊的制备及其体外释放.doc

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法莫替丁脉冲控释的微丸胶囊的制备及其体外释放

法莫替丁脉冲控释微丸胶囊的制备及其体外释放 352[N[NDrugevaluafion?f2004V01?o1No?o5 ???????3?v?????????F???????H?g???????6???B ???????? ?[??1??s?x2???????f?[???l2 (1???)?H???????????N???????v???-???????H?=???f???????f050015?R2???y?????s???????????=???f???y?f 110016?R3???)?I???s???_???,???I???f???????f050011) b0????b4?????H?g?????????3?x?A?????????v???????????R???7?H?g?v?????F??????b5???????c?8???? ?u???H?g?9?????Fb5???c?v?x???????x?u?H?g?v?????F?f???F???C?????v?x???fEudragitRSl00?x?r???????f?c ?????????E?6?D??b5?u?8?????F???e?o?H?0?v?????????F????b5?????v???????????????6???B?u?x?8???t ?9?????F???9?????f?????????B??30min??50?r?R?v?????F??5h?????????????f?G?????B??13h????95?rb5?v ?????F???????j?F???C???????r???????????f?????R?f?????o???????9???d?I???j??r???Hb5???????c ?v?x???????x?u???H?g?u?????v?????F?R?o?9?????F???e?????H?0?????8?A?????????3?v?????????F????b5 b0???w??b4???????3?R???????u???R?v?????F?R?8?????u?[???R?v?x???????????????? [?C???u????b4R943b0???w?g???3b4Ab0?????6??b41672-2809(2004)05-0352--04 Preparationandinvitroreleaseoffamotidinepulsed-releasecapsule?o ZhongLiJ,ChenDawei2,GA0Zibin3,eta1?o(1Departmentofpharmaceutics?fNewDrugResearch andDevelopmentCo?oLtd?o?fNorthChinaPharmaceuticalGroupCorp?o?fShijiazhuang,050015,Chino,- 2Departmentofpharmaceutics?fSchoolofpharmacy?fShenyangPharmaceuticalUniversity, Shenyng110016,China?R3?oThefourthhospitalofHebeimedcaluniversity,Shijiazhuang050011?f China) AbstractObjectiveTopreparepulsed[Nreleasecapsule(PRC)usingfamotidine(FM)asamodel drugandtoexplorethewayofpreparingpulsed[Nreleasepellets(PRP)?oMethosdNormalpellets (NP)werepreparedbyextrusion-spheronization?oPRPwere[mOrganicacid-inducedtypedrugdeliv[N erysystem[m(OAITDDS)?fwithorganicacidinthecore?fEudragitRSl00asthecoating?fusingorthog- onaltestdesigntooptimizetheformulation?oThetwokindsofpelletsweremixedtoprepareFM PRC?oResultsThereleaseofPRChadtwostepsinvitro?oFirst?fNPreleaseddrugquicklyandthe cumulativereleasequantitywasneady50?rwithin30min?oSecond?oPRPreleasewasinitiatedafter ???r??