Treatments in Type 2 Diabetes Welcome Kent LPC在2型糖尿病患者的欢迎肯特LPC的药物治疗课件.pptVIP

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Treatments in Type 2 Diabetes Welcome Kent LPC在2型糖尿病患者的欢迎肯特LPC的药物治疗课件.ppt

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Treatments in Type 2 Diabetes Welcome Kent LPC在2型糖尿病患者的欢迎肯特LPC的药物治疗课件

* T2D – the Challenge Treating T2D presents many challenges. The core defects of insulin resistance and diminishing ?-cell function must be addressed, but at the same time the patients’ cardiovascular health must be protected as much as possible. Hence it is important to not only strive to achieve glycaemic control, but to also measure blood pressure and blood lipids and treat appropriately. Such an approach inevitably leads to polypharmacy and patients may need to take several tablets per day. This introduces problems of concordance with therapy that may compromise outcome. In the DARTS study (Diabetes Audit and Research in Tayside Scotland) Donnan et al. tested the hypothesis that taking one tablet per day was associated with better adherence than taking multiple tablets, in a retrospective cohort of 2920 patients with Type 2 diabetes receiving at least 12 months prescriptions with a single oral antidiabetic agent. Adequate adherence (90%) was found in 31% or 34% of those prescribed sulphonylurea or metformin alone, respectively. Additionally, there were significant trends of poorer adherence with each increase in co-medication for sulphonylureas alone after adjustment for other factors (p=0.0001) and the number of sulphonylurea tablets taken per day (p=0.001). Donnan et al Diabetic Medicine, 2002;19:279-84. * * UKPDS: a 1% Reduction in HbA1c Significantly Reduced the Risk of Diabetes-related Complications This slide shows results from the UKPDS study, demonstrating that a 1% reduction in HbA1c can reduce the risk of diabetes related complications This study and other supporting evidence has led to the current glycaemic targets set out in various guidelines for the management of Type 2 diabetes. For example: NICE 6.5% and 7.5% QOF Target HbA1c 7.0, 8.0 and 9.0% ADA/EASD 7% (aiming for normal glycaemia) IDF 6.5% * * Pharmacologic Targets of Current Drugs Used in the Treatment of T2D The number of antihyperglycemic drugs for use either alone, in combina