盐酸戊乙奎醚对腹腔镜下胃癌根治术围术期胃动素和胃泌素影响.docVIP

盐酸戊乙奎醚对腹腔镜下胃癌根治术围术期胃动素和胃泌素影响 　　[摘要] 目的 研究盐酸戊乙奎醚对腹腔镜下胃癌根治术围术期胃泌素（GAS）和胃动素（MTL）的影响。 方法 选择2010年1月～2012年12月广州中医药大学附属北碚中医院行腹腔镜下胃癌根治术患者200例为研究对象，随机分为麻醉前给予盐酸戊乙奎醚肌内注射的观察组和麻醉前给予常规处理的对照组，每组各100例。观察两组患者进入手术室时（T0）、术中（T1）、手术结束时（T2）、术后1 d（T3）、术后2 d（T4）时各血液动力学指标及MTL、GAS含量。 结果 ①T0、T1、T2、T3、T4时间点，两组患者收缩压的差异无统计学意义（P 0.05）；T0、T1时间点，两组患者MTL和GAS含量的差异无统计学意义（P 0.05）。②T2、T3、T4时间点，观察组患者的GAS含量[（78.2±10.5）、（63.8±8.2）、（89.4±12.1）pg/mL]均高于对照组[（57.5±7.9）、（41.9±6.7）、（72.3±9.4）pg/mL]，两组相比，差异均有统计学意义（均P 　　[关键词] 盐酸戊乙奎醚；胃癌根治术；胃动素；胃泌素 　　[中图分类号] R971.92 [文献标识码] A [文章编号] 1673-7210（2014）01（c）-0095-03 　　Effect of penehyclidine hydrochloride on motilin and gastrin in perioperative period of patients with gastric cancer undergoing radical correction under laparoscope 　　MA Chun1 YANG Anbo2▲ 　　1.Department of Anesthesiology， the Fuling Central Hospital of Chongqing City， Chongqing 408009， China； 2. Department of Anesthesiology， Beibei Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine， Chongqing 400700， China 　　[Abstract] Objective To study the effect of Penehyclidine Hydrochloride on motilin （MTL） and gastrin （GAS） in perioperative period of patients with gastric cancer undergoing radical correction under laparoscope. Methods 200 patients with gastric cancer undergoing radical correction under laparoscope in Beibei Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine from January 2010 to December 2012 were selected and randomly divided into observation group given Penehyclidine Hydrochloride injection before anesthesia and control group given conventional treatment before anesthesia. Then hemodynamic indexes， levels of MTL motilin and GAS were observed when proceeding into operating room （T0）， in operation （T1）， finishing operation （T2）， 1 day after operation （T3）， 2 days after operation （T4）. Results ①At T0， T1， T2， T3， and T4 time point of perioperation period， there were no significant difference b