铜绿假单胞菌临床感染分布及耐药现状分析.docVIP

铜绿假单胞菌临床感染分布及耐药现状分析 　　【摘要】 目的：了解铜绿假单胞菌（PAE）的临床感染分布及耐药现状，为预防和控制医院感染及合理用药提供依据。方法：采用常规方法对本院细菌室收集的临床标本进行菌株鉴定及药敏试验。结果：2009年1月-2012年12月间共分离出98株铜绿假单胞菌，标本来源以痰为主占73.5%（72/98），科室分布以内科系统（含重症监护病房）最多，占71.4%（70/98）。对磺胺甲恶唑/甲氧苄啶、头孢曲松、左氧氟沙星、庆大霉素、环丙沙星、妥布霉素等多种抗生素的耐药率均较高，分别为90.8%、66.3%、52.0%、51.0%、50.0%、44.9%。结论：铜绿假单胞菌是医院内感染的主要病原菌之一，随着分离率和耐药性的上升，应做好医院感染控制和抗菌药物分级管理工作，加强细菌培养及药物敏感试验，根据结果合理选用抗菌药物，减少或防止耐药菌株的产生或播散。 　　【关键词】 铜绿假单胞菌； 医院感染； 药物敏感试验； 抗菌药物 　　Pseudomonas Aeruginosa Clinical Infection Distribution and Drug Resistance Present Condition Analysis/REN Bao-yan.//Medical Innovation of China，2013，10（35）：152-154 　　【Abstract】 Objective：To understand Pseudomonas aeruginosa （ PAE ） infection clinical distribution and drug resistance situation.To provide basis for the prevention and control of hospital infection and rational drug use. Method： Strain identification and drug sensitive test of clinical specimens collected in our bacteria chamber were done by conventional method.Result： 98 strains were separated between the pseudomonas aeruginosa from January 2009 to December 2012， specimens were from sputum accounted for 73.5% （72/98）.Distribution of departments in Department of internal medicine （ICU system containing） the most， accounting for 71.4%（70/98）.Resistance to sulfamethoxazole/ trimethoprim variable ceftazidime，ceftriaxone，levofloxacin， ciprofloxacin，gentamicin，tobramycin and multiple antibiotic resistance rate were higher，respectively，90.8%，66.3%，52%，51%，50%，44.9%. Conclusion：Pseudomonas aeruginosa nosocomial infection is one of the main pathogenic bacteria，along with the separation rate and resistance， the rise of the hospital infection control should be done and antimicrobial drug classification management work， strengthens the bacterial culture and drug sensitive test， according to the result is reasonable to choose antimicrobial agents，to reduce or prevent drug-resistant strain generation or broadcast. 　　【Key words】 Pseudomonas aeruginosa； The hospital infection； Drug sensitiv