银杏达莫注射液对高血压合并肾功能不全患者血脂及肾功能影响.docVIP

银杏达莫注射液对高血压合并肾功能不全患者血脂及肾功能影响 　　[摘要] 目的 观察银杏达莫注射液对高血压合并肾功能不全患者血脂及肾功能的影响。 方法 将我院78例高血压肾功能不全患者随机分为对照组（38例）和银杏达莫组（40例），对照组给予常规降压，银杏达莫组在常规降压基础上，给予银杏达莫注射液30 mL，每日1次，疗程为3周，观察两组患者血压、血脂、肾功能的变化，记录其不良反应。结果 银杏达莫组在降低患者24 h尿蛋白排泄量、BUN、Scr，升高HDL-C、Ccr方面均优于对照组（P 　　[关键词] 银杏达莫；高血压；肾功能不全；血脂 　　[中图分类号] R277.5 [文献标识码] B [文章编号] 1673-9701（2014）02-0033-03 　　Effect of ginkgo leaf extract and dipyridamole injection on the renal function and the blood lipid of patients with hypertension complicated with renal insufficiency 　　WANG Xiafei1 BO Shuangshan1 WU Yongliang2 　　1.Department of Internal Medicine，the Peoples Hospital of Dongyang City in Zhejiang Province， Dongyang 322100，China； 2.The People’s Hosptial of Xinchang County in Zhejiang Province， Xinchang 312500， China 　　[Abstract] Objective To study the effect of ginkgo leaf extract and dipyridamole injection on the renal function and the blood lipid of patients with hypertension complicated with renal insufficiency. Methods The hypertension complicated with renal insufficiency patients were recruited and randomly assigned to the control group（38 cases） and the ginkgo leaf extract and dipyridamole group（40 cases）. All patients received conventional antihypertensive treatment. but those ni the Ginkgo leaf extract and dipyridamole group received Ginkgo leaf extract and dipyridamole injection 30 mL ivgtt qd additionally. The observation was lasted for 3 weeks. The blood pressure， blood lipid and the indices of the renal functions were observed before and after treatment. Results After 3 weeks of treatment， better effects in reducing the 24 h protein excretion in urine，BUN，Scr and increasing HDL-C，Ccr were obtained in the ginkgo leaf extract and dipyridamole group than in the control group（P 　　1.2一般资料 　　我院自2012年6月～2013年6月共收治的78例原发性高血压性肾功能不全患者均符合上述纳入标准并且不符合排除标准。其中男45例，女33例，年龄59～78岁，平均（67.9±4.6）岁，病程10～25年，平均（15.3±5.6）年。随机分为对照组38例和银杏达莫组40例，对照组男22例，女16例，平均年龄（66.1±4.1）岁，病程（16.1±5.3）年；银杏达莫组男23例，女17例，平均年龄（69.1±3.5）岁，病程（15.8±4.8）年。两组患者性别、年龄、病程等一般