Cell Biology of Salivary Protein Secretion：唾液腺分泌蛋白的细胞生物学.pptVIP

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2018-06-23 发布于浙江
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Cell Biology of Salivary Protein Secretion：唾液腺分泌蛋白的细胞生物学.ppt

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Cell Biology of Salivary Protein Secretion：唾液腺分泌蛋白的细胞生物学

Cell Biology of Salivary Protein SecretionBiology of salivary glands (BMS 513)Nisha D’Silva DDS, PhDMonday, June 3, 20029 - 10 am, Rm G322 Overview 1. Review anatomy and Histology 2. Secretory pathways 3. Signaling mechanism in regulated secretion. 4. Brief discussion about drugs and saliva. Macromolecule secretion Polypeptides and proteins are synthesized and secreted by the salivary acinar cells Sublingual saliva -- very thick and viscous produced by mucous acinar cells Parotid saliva -- thin and watery produced by serous acinar cells mainly salivary amylase and proline-rich polypeptides Submandibular saliva -- intermediate consistency a mix of serous and mucous acini Regardless of the type of protein Too large to cross the cell membrane Must be synthesized and stored within a membrane-bound vesicle and released by exocytosis Protein synthesis and secretory pathways Protein synthesis and secretion Genes transcribed in nucleus to make mRNA Message is transferred to ribosomes in cytoplasm Secretory proteins begin with signal sequence which targets developing peptide to endoplasmic reticulum At ER, peptide is N-glycosylated and folded into correct 3D structure Small membrane vesicles carry proteins from ER through several layers of the golgi apparatus for additional processing and packaging for export Protein synthesis and secretion (cont’d) Proteins move by default onwards from the ER Specific retention sequences segregate non-secreted proteins Secretory proteins are concentrated and stored in secretory vesicles Mature vesicles are transported to apical membrane Secretory stimuli result in vesicle fusion with plasma membrane Contents of vesicles are discharged outside of cell Secretory pathways 1. Constitutive - occurs continuously 2. Regulated 3. Paragranular - small vesicles break-off from SGs that undergo regulated secretion and are released Constitutive exocytosis Differs from regulated exocytosis Proteins not concentrated into secretory vesicles awaiting e