Hemolytic disease of the newborn is caused primarily by ：新生儿溶血病的主要是由于.pptVIP

Topics Transplantation immunity Autoimmune diseases Immunodeficiency disorders Transplantation immunity Transplantation immunity Allografts Xenografts Genetically non – identical grafts cause rejections Type IV reaction – delayed cell-mediated Immunological rejection of transplant Killing of graft by sensitized cytotoxic T cells Natural killer cells (ADCC) MHC antigens major cause of rejection abundant on leukocytes = HLAs tissue typing minimizes incompatibility Transplantation immunity Allografts Xenografts Genetically non – identical grafts cause rejections Type IV reaction – delayed cell-mediated Immunological rejection of transplant Killing of graft by sensitized cytotoxic T cells Natural killer cells (ADCC) MHC antigens major cause of rejection Requires immunosuppression for successful transplants minor antigens cause rejection immunosuppressants may be needed indefinately Transplantation immunity Allografts Xenografts Genetically non – identical grafts cause rejections Type IV reaction – delayed cell-mediated Immunological rejection of transplant Killing of graft by sensitized cytotoxic T cells Natural killer cells (ADCC) MHC antigens major cause of rejection Requires immunosuppression for successful transplants Cyclosporin A, tacrolimus interfere with cell signaling inhibit clonal expansion of T cells specificity leads to fewer side effects than radiation and cytotoxicity inhibitors Autoimmune disease Autoimmune disease Spectrum of autoimmune reactions Treatment of autoimmune diseases Treatment of autoimmune diseases Immunosuppressants (eg cyclosporins) Anti – inflammatory drugs (eg steroids) Replacement therapy (eg insulin, thyroid hormone) including transplantation of pancreatic insulin-producing cells for insulin-dependent diabetes Treatment of autoimmune diseases Immunosuppressants (eg cyclosporins) Anti – inflammatory drugs (eg steroids) Replacement therapy (eg in