INTERNATIONAL COLLABORATIVE SYSTEMATIC REVIEW …：国际合作的系统评价….pptVIP

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INTERNATIONAL COLLABORATIVE SYSTEMATIC REVIEW …：国际合作的系统评价….ppt

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INTERNATIONAL COLLABORATIVE SYSTEMATIC REVIEW …：国际合作的系统评价…

M. Lotrionte1, C. Moretti2, M. Imazio3, A. Abbate4, P. Di Pasquale5, M. Raatikka6, A. Brucato7, I. Sheiban2, G. Biondi-Zoccai2 1Unità di Scompenso Cardiaco e Riabilitazione, Complesso Integrato Columbus, Roma, Italy; 2Divisione di Cardiologia 1, Ospedale San Giovanni Battista Molinette, Torino, Italy (gbiondizoccai@), 3Divisione di Cardiologia, Ospedale Maria Vittoria, Torino, Italy 4VCU Pauley Heart Center, Richmond, VA, USA, 5Divisione di Cardiologia, Ospedale G. F. Ingrassia, Palermo, Italy 6Department of Pediatrics, Children Hospital, Helsinki, Finland 7Dipartimento di Medicina Interna, Ospedali Riuniti, Bergamo, Italy This work was supported by the Agenzia Italiana del Farmaco (AIFA), with grant FARM7X58KC Acute pericarditis is common and can often recur. Despite widespread agreement on the usefulness of non-steroidal anti-inflammatory drugs (NSAIDs), uncertainty persists on the role of other agents on top or in lieu of NSAIDs. We thus aimed to conduct a comprehensive systematic review on pharmacologic treatments for acute or recurrent pericarditis. Potentially relevant studies published up to September 2009 were searched in BioMedCentral, The Cochrane Collaboration Database of Randomized Trials (CENTRAL), ClinicalT, EMBASE, Google Scholar, MEDLINE/PubMed, and Scopus. Studies were included provided they focused on pharmacologic agents for acute pericarditis or its recurrences. Random-effect odds ratios (OR) were computed for long-term treatment failure, pericarditis recurrence, rehospitalization, and adverse drug effects. From 2078 citations, 7 studies were finally included (451 patients), but only 3 were randomized trials. Treatment comparisons were: colchicine vs. standard therapy (3 studies-265 patients), steroids vs. standard therapy (2 studies-31 patients), low-dose vs. high-dose steroids (1 study-100 patients), and statins vs. standard therapy (1 study-55 patients). Colchicine was associated with a reduced risk of treatment failure (OR=0.23 [0.