Molecular genetics of gene expression - University of ：基因表达的分子遗传学大学.pptVIP

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Molecular genetics of gene expression - University of ：基因表达的分子遗传学大学.ppt

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Molecular genetics of gene expression - University of ：基因表达的分子遗传学大学

* * * * * * * * * * * * * * AUG UCG ACA GGC UGA Initiation of translation Assembly of the small ribosomal subunit and initiator tRNA onto the mRNA The start codon is found by scanning downstream from the 5’ end of the mRNA VIDEO Amino acid backbone 20 amino acids Discussion questions What are the differences between DNA and RNA? Describe the main parts of a gene and their functions. What role do cis-regulatory elements and trans-acting factors play in gene regulation? What is responsible for the wide diversity of protein structure found in nature? In what different ways can gene expression be regulated? Gene expression regulation Transcriptional level: Transcription factors (environmental, physiological) Alternate splicing Translational level: Elongation factors RNA interference Discussion questions What are the differences between DNA and RNA? Describe the main parts of a gene and their functions. What role do cis-regulatory elements and trans-acting factors play in gene regulation? What is responsible for the wide diversity of protein structure found in nature? In what different ways can gene expression be regulated? /watch?v=GkdRdik73kU /watch?v=GkdRdik73kU * * * * * * * * * * * * * * * * * * * * Molecular genetics of gene expression Mat Halter and Neal Stewart 2014 Discussion questions What are the differences between DNA and RNA? Describe the main parts of a gene and its functions. What role do cis-regulatory elements and trans-acting factors play in gene regulation? What is responsible for the wide diversity of protein structure found in nature? In what different ways can gene expression be regulated? /cells.php A Chromosome is composed of nucleosome-bound DNA called chromatin The nucleosome Fig F09-30A. Nucleosome structure. (Lodish et al., 2000). Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid April 25, 1953 Francis Crick James Watson Figure 6.2 http://www.stern.de/_content/50/44/504453/watson_crick_500.jpg A’s pair with