孤立性颤的临床特征分析.docVIP

孤立性房颤的临床特征分析 北京大学第三医院心内科（北京，100083） 王淑敏 陈凤荣 北京大学人民医院心内科（北京，100044） 张 萍 【摘要】 目的 分析孤立性房颤临床特征对其预后及结局的影响。方法 共收集孤立性房颤(LAF)104例，高血压房颤(HPAF)49例，以高血压房颤组为对照，采用单因素的χ2检验和多因素的逐步Logistic 回归方法，对孤立性房颤的性别、年龄、并发症、家族史等临床特征及超声心动图指标进行分析。结果 与HPAF组相比，LAF组左房增大患者检出率较低（P值＝0.041），低龄发病患者较多（P值＝0.029）；无论在孤立性房颤组（P值＝0.016）还是在高血压房颤组（P值＝0.047），持续性房颤患者并发症检出率均较高；左房增大与房颤持续性、左室舒张末内径及高血压呈正相关。结论 在孤立性房颤患者，不同的临床特征具有不同的自然病程及结局，其中左房扩大是一个重要的预后因子。 【关键词】 孤立性房颤 临床特征 预后 The analysis of clinical features of lone atrial fibrillation Wang Shumin1, Chen fengrong1 ,Zhang ping2, 1 (Department of Cardiovascular Diseases, Peking university third hospital,Beijing 100083, China;E-mail: shuminw@163.com);2(Department of Cardiovascular Diseases, Peoples Hospital of Peking University, Beijing, 100044, China) 【Abstract】 Objective The study was conducted to investigate the association between clinical features of lone atrial fibrillation and outcomes. Methods one hundred and four patients with lone atrial fibrillation (LAF)and 49 patients with atrial fibrillation and hypertension (HPAF)were enrolled. Clinical data of all patients were collected . Results By univariate analysis , patients with left atrial dilation were less in LAF group than in HPAF group,but the number of early onset patients was larger in LAF group.More complications were found in patients with persistent atrial fibrillation than in patients with paroxysmal atrial fibrillation in both groups. By logistic regression analysis, left atrial dilation in patients with atrial fibrillation was positively related with hypertension, left ventricle dilation and persistent atrial fibrillation. Conclusions Outcomes of patients with lone atrial fibrillation varied with clinical features, and left atrial dilation was an important predictor of prognosis. 【Key words】 lone atrial fibrillation clinical features left atrial dilation 孤立性房颤是一种无任何器质性心脏病证据的房颤，尽管一些临床试验表明，此类房颤预后较好，但它不总是一种良性病程，对某些患者仍需要积极采取措施干预，以改善症状，减少并发症发生。本文以高血压房颤患者为对照，旨在通过对一组孤立性房颤患者临床资