三七治疗冠心病系统评价-中药学专业论文.docx

组和丹参组，对降低患者纤维蛋白原、全血黏度和全血高切变率的作用与丹参制剂无区别，优于西医常规组。所有研究均未对病死率、长期疗效、生活质量等重要指标进行观察。结论：三七制剂治疗冠心病的疗效肯定、不良反应及副作用较少，症状较轻，是较安全的制剂。由于纳入的文献质量偏低,样本量小,分配隐藏不充分,大多数没有使用盲法，因此在使用本证据的时候要谨慎，期待大样本，高质量的临床随机对照试验进一步验证。关键词：三七；冠心病；系统评价；Meta分析ASystematicReviewofPanaxNotoginsengforCoronaryHeartDiseaseabstractObjective:ToevaluatetheefficiencyandsafetyofPanaxnotoginsenganditspreparationsforCoronaryHeartDiseaseandprovideevidencefordevelopmentofnewSanqipreparationsandclinicalapplication.Methods:Theeligiblestudieswereincludedbyhandsearchingandelectronicsearching.Tworeviewersindependentlyscreenedthestudiesforeligibility,evaluatedthequalityandextractedthedatafromtheeligiblestudies,withconfirmationofcross-check.Differentopinionswouldbedecidedbythethirdparty.Thequalityofincludedstudies,suchasrandomization,blinding,allocationconcealmentandfollowing-upwasevaluated.Meta-analysiswasperformedbyusingRevMan5.0software.Afterheterogeneitytest,datawithoutheterogeneitycouldbepolledbyusingfixedeffectmodel,andthosewithheterogeneitycouldbesolvedbysensitivityanalysis,subgroupanalysisaswellasrandomizedeffectmodel.Wewillcompareoutcomemeasuresforbinarydatausingrelativerisks(RR)with95%confidenceintervals(CI).Forcontinuousdata,theweightedmeansdifference(WMD)willbeused.Results:Thenon-experimentalclinicaltrailsindicatedthatsingleuseofPanaxnotoginsengwaseffectiveforimprovementofsignsandsymptomsofpatientswithanginapectoris;quasi-experimentalresearchesshowedthatPanaxnotoginsengwassuperiortoWMandDSinthecurativeeffectandECG,aswellashemorheologicalparameters.Meta-analysisshowedthatPanaxNotoginsenosidum(PNS)wasbetterthanwesternmedicine(WM)intreatmentofunstableanginapectoris(UAP),andothertypesofanginapectoris(AP).Forstableanginapectoris(SAP),therewasnodifferencebetweentwogroupsinsymptomimprovementbutPNSwasbetterthanWMinelectrocardiogram(ECG)improvement.TherewasnodifferencebetweenPNSandDanshenpreparations(DSP)forthetreatmentofSAP.ForvarioustypesofAP,PNSwassuperiortoDanshenpreparations.Fortreatmentofothertypesofanginapectoris,PNSwass