湿润烧伤膏加速肛管皮肤慢性难愈合创面愈合的临床与实验分析-中医外科学专业论文.docxVIP

基础上，为创面提供必需营养物质，调动休眠的组织细胞分裂增殖，以再生方式重新建立向心移行生长，从而加速创面的愈合。结 论：临床研究表明，MEBO 加速了肛管慢性难愈合创面的愈合， 有较好的临床疗效及较高的安全性。实验研究表明，MEBO“以液化的方 式无损伤性的排除坏死组织”和“以原位再生的方式修复创面”加速了肛管 慢性难愈合创面的愈合；MEBO 通过促进细胞分裂纤维细胞增殖，改善 创面的血液循环，调控胶原的合成及代谢，调节创面修复基质的形成， 营养创面等来发挥多途径、多靶点、多环节、多层次的综合调控作用， 提高机体本身修复能力，从而促进肉芽生长、加速创面愈合、缓解伤口 疼痛、减少瘢痕形成；MEBO 促进创面愈合的作用与 rhEGF 相近，并具 有价格便宜，保存时间长，湿润伤口的优点。关键词：湿润烧伤膏；肛管皮肤难愈合创面；临床观察;实验研究Anal skin MEBO accelerate the healing of chronic wounds Clinical and Experimental Research ABSTRACTObjective：MEBO treatment of anal canal in chronic wounds of the clinical efficacy, and by light microscopy and electron microscopy the ultrastructure of new granulation tissue to assess the difficulty of MEBO on the healing of wounds in rats to study the MEBO anal skin, the principle ofchronic wounds.Methods：Clinical Research Methods A randomized comparison of 87 patients met the inclusion criteria were divided into treatment group (30 cases), control group 1 (29 cases) and control group 2 (28 cases), respectively, to the MEBO, bFGF, Vaseline gauze for drugs, drug 3,7,14,21,28 days observed ineach group and the general situation of the wound medication efficacy, healing, healing of scar formation, and make statistical analysis Experimental Study 60 guinea pigs were divided into modeling after successful treatment group and control group 1, 2, 20 patients in the control group. Were to MEBO, bFGF, Vaseline gauze, wound dressing changes were observed during the general situation, the growth of granulation and wound closure index, and were taken in the same part of dressing 3,7,14,21 days wound granulation tissue fixed in formaldehyde underwent HE staining of wound granulation tissue generally; take 3-14 days dressing the same part of granulation tissue underwent 2.5% glutaraldehyde fixed specimens were observed by electron microscope observation of the ultrastructure including cell subcellular structure, the relationship between cells and capillaries, collagenResults: The results of clinical studies Trea