吡格列酮对2型糖尿病大鼠肝脏及nf-κb mcp-1表达的影响-effect of pioglitazone on expression of nf - κ b mcp - 1 in liver of type 2 diabetic rats.docxVIP

中英文缩写对照表缩写ACR英文名称urinaryalbumin/creatinineratio中文名称尿白蛋白/尿肌酐AGEsadvancedglacationendproducts蛋白非酶糖基化产物AgIIALTangiotensinIIalanineaminotransferase血管紧张素II谷丙转氨酶AP-1activatorprotein-1激活蛋白-1BMBMIbodymassbodymassindex体重体重指数ELISAenzyme-linkedimmunosorbent酶联免疫吸附法assayERendoplasmicreticulum内质网ERKExtracellularsignal细胞外信号调节激酶regulatedproteinkinaseFBGfastingperipheralbloodglucose空腹血糖FBSfetalbovineserum胎牛血清FINSFLCfastinginsulinfattylivercirrhosis血浆胰岛素肝硬化Gly-AlbGSHGsh-pxglycatedalbuminglutathioneglutathioneperoxidase糖基化白蛋白还原型谷胱甘肽谷胱甘肽过氧化物酶HbA1cHSCglycosylatedhemoglobinA1chepaticstellatecell糖化血红蛋白A1c肝星状细胞κIBinhibitorofkappaB核因子-κB抑制蛋白ICAM-1intercellularadhesionmolecule-1细胞间黏附分子-1IKK-βIL-6IRISIMAC-1MCP-1MetSMIP-1αNAFLNAFLDNASHNF-κBP38MAPKIκBkinaseinterleukin-6insulinresistanceinsulinsensitivityindexmacrophageantigen-1monocytechemoattractantprotein-1metabolicsyndromemacrophageinflammatoryprotein-1αnonalcoholicfattylivernonalcoholicfattyliverdiseasenonalcoholicsteatohepatitisnuclearfactor-κBp38mitogenactivatedproteinkinaseIκB激酶白细胞介素-6胰岛素抵抗胰岛素敏感指数巨噬细胞抗原-1单核细胞趋化蛋白-1代谢综合征巨噬细胞炎性蛋白-1α单纯性脂肪肝非酒精性脂肪肝非酒精性脂肪性肝炎核因子-κBp38丝裂原活化蛋白激酶PIOpioglitzone吡格列酮PKCPKRPPAR-?ROSSAPKsproteinkinaseCRNA-dependentproteinkinaseperoxisomeproliferation-activatedreceptorgamma?reactiveoxygenspeciesstress-activatedproteinkinases蛋白激酶CRNA依赖的蛋白激酶过氧化物酶体增殖物激活受体γ活化氧自由基应激活化蛋白激酶SMCP-1serummonocytechemoattractantprotein血单核细胞趋化蛋白-1SPSSstatisticalpackageforsocialscience社会科学统计软件包STZstreptozotocin链脲佐菌素TCcholesterol胆固醇T2DMtype2diabetesmellitus2型糖尿病TGtriglyceride甘油三酯TGF-βtransforminggrowthfactor-β转化生长因子-βTNF-αtumornecrosisfactor-α肿瘤坏死因子-αTZDsthiazolidinediones噻唑烷二酮类UMCP-1UPRurinarymonocytechemoattractantprotein-1acomponentoftheunfoldedproteinresponse尿单核细胞趋化蛋白-1未折叠蛋白反应URBPurinaryretinolbinding-protein尿视黄醇结合蛋白VCAM-1vascuolarcelladhesionmolecule-1血管内皮细胞粘附分子-1吡格列酮对2型糖尿病大鼠肝脏及NF-κB、MCP-1表达的影响中文摘要目的观察吡格列酮（pioglitzone，PIO）对2型糖尿病（type2diabetesmellitus，T2DM）大鼠肝脏组织功能与结构、核因子-κB（nuclearfactor-κB，NF-κB）、单核细胞趋化蛋白-1（monocytechemoattractantprotein-1，MCP-1