青岛大学基础医学院医学免疫学课件 chapter21.ppt

Chapter 21 Immunodeficiency Disease Topics on medical immunology Endoscopic imaging of the duodenum shows multiple prominent nodules 3–5 mm in size, consistent with nodular lymphoid hyperplasia A child with severe combined immunodeficiency showing skin lesions due to infection with vaccinia gangrenosum resulting from smallpox immunization. Lesions were widespread over the whole body. 1. X-linked SCID, XSCID 2. Autosomal recessive heredity SCID MHC-I derangements Mutation of TAP gene Endogenous Ag can’t be transported on endoplasmic reticulum MHC-II derangements (Bare lymphocyte syndrome,