高脂饮食兔腹主动脉缩窄前后内膜平滑肌细胞和胶原变化-changes of intimal smooth muscle cells and collagen in rabbits with high fat diet before and after abdominal aorta constriction.docxVIP

9.42±0.29)kPa, P＜0.05], and lower in the distal of the constriction than that inhigh-lipid sham operation group[(6.99±0.79 vs 7.84±0.48)kPa, P＜0.05].③ The intima was thin and glossy in common sham operation group. There were a lot of foam cells in the intima of high-lipid operation group and high-lipid sham operation group. The intima was thicker in the proximate of constriction in high-lipid operationgroup than that in high-lipid sham operation group[(183.76±10.53 vs 164.59±4.9)μm, P ＜ 0.05], and thinner in the distal than that in high-lipid sham operation group[(118.63±13.35 vs 136.84±6.28)μm, P＜0.05].④Smooth muscle cells and collagen were more in the proximate of constriction in high-lipid operation group than those in high-lipid sham operation group[Smooth muscle cells: (0.23±0.01 vs 0.15±0.02)OD, collagen: (0.27±0.05 vs 0.18±0.01)OD, P＜0.05], and less in the distal than those in high-lipid sham operation group[(0.06±0.03vs 0.09±0.01)OD, (0.09±0.02 vs 0.13±0.01)OD, P＜0.05].Conclusion The blood pressure was higher in the proximate of constriction in high-lipid operation rabbit’s abdominal aorta, and the intima was thicker, smooth muscle cells and collagen were more. With the blood pressure gradual declining, All the above were less in the distal of constriction.Key words: rabbit; atherosclerosis; collagen; smooth muscle cells英文缩略词表（abbreviations）英文缩写AS英文全称atherosclerosis中文全称动脉粥样硬化LDLlow density lipoprotein低密度脂蛋白Ox-LDL NO VSMC ET-1CHDoxidation low density lipoprotein nitric oxide vascular smooth muscle cell endothelin -1coronary heart disease氧化的低密度脂蛋白 一氧化氮 血管平滑肌细胞 内皮素-1 冠状动脉性心脏病ECM IL OD TCTGextracellular matrix interleukinoptical density total cholesteroltriglyceride细胞外基质 白介素 光密度值 总胆固醇 甘油三酯α-actin MMP M-CSF NOSDABα-smooth muscle actin matrix metalloproteinasemonocyte colony stimulating factor nitricoxide synthasediaminobenzidineα平滑肌肌动蛋白 基质金属蛋白酶 单核细胞集落刺激因子 一氧化氮合酶 二氨基联苯胺APS PBSPHammonium persulfate phosphate buffered solutionpower of hydrogen过硫酸铵 磷酸缓冲液 酸碱度