骨髓增生异常综合征患者p15ink4b、fhit基因甲基化的研究-methylation of p 15 ink 4b and fhit genes in myelodysplastic syndrome.docxVIP

下载本文档

3
0
约3.71万字
约 38页
2018-07-05 发布于上海
举报
版权申诉

骨髓增生异常综合征患者p15ink4b、fhit基因甲基化的研究-methylation of p 15 ink 4b and fhit genes in myelodysplastic syndrome.docx

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

骨髓增生异常综合征患者p15ink4b、fhit基因甲基化的研究-methylation of p 15 ink 4b and fhit genes in myelodysplastic syndrome

山西山西医科大学硕士学位论文IVIVwere 15.4%, 51.9% and 70.0%, respectively,the methylation positive rates of FHIT gene were 7.7%, 40.7% and 60.0%, respectively.The differences among three groups are significant（χ 2=7.596,,P=0.022; χ2=7.285,P=0.026），the methylation level of low-risk/inter-risk-1 group islower than high-risk group, and the differences between two groups are significan（tP0.05/3）;but the differences between low-risk/inter-risk-1 group and inter-risk-2 group , between inter-risk-2 group and high-risk group are not significant; the methylation between P15INK4B gene and FHIT gene is not relevant.As the progression of the disease, CD34 positive cells gradually increased：refractory anemia/ring sideroblasts refractory anemia (RA/RAS) 7.43%，refractory anemia with excess of blasts (RAEB) 36.81%，refractory anemia with excess of blasts transformed (RAEB-T) 56.45%, andthe differences were statistically significant (P 0.05); the expressions of CD33, CD13 and HLA-DR increased gradually, the expressions of CD14 and CD15 antigens gradually decreased,the difference of three groups was statistically significant (P0.05); the expression of CD19 and CD10 were decreased as the progression of the disease , the expression of CD19 were3.05%、2.04% and 1.05%,respectively;the difference of three groups was statistically significant(F=8.236，P=0.002), the differences between any other two groups were statistically significant (P0.05); the expression of CD10 were 9.95%、8.07% and 3.67%,respectively;the difference of three groups was statistically significant (F=6.919，P=0.004), the differences between RA/RASand RAEB-T, RAEB and RAEB-T were statistically significant (P0.05); the expression of CD19 and CD10 were decreased and the expression of CD7 was increased(RA/RAS 2.63%、RAEB 10.79% and RAEB-T 11.00% ) with the progression of the disease, the difference of three groups was statistically significant (P 0.05), the differences between RA/RAS and RAEB, RA/RAS and RAEB-T were statistically sig