156株耐喹诺酮类抗生素炎克雷伯菌药敏结果分析.docVIP

156株耐喹诺酮类抗生素肺炎克雷伯菌药敏结果分析 　　【摘要】 目的：调查分析坪山坑梓地区肺炎克雷伯菌（Klebsiella pneumoniae，Kp）对喹诺酮类抗生素的耐药性。方法：回顾性分析2014年8月-2017年8月本院就诊患者送检标本2 659份中分离出的非重复性Kp对喹诺酮类抗生素的耐药株数量。结果：2 659标本中分离出511株Kp，检出率为19.2%，其中ESBLs菌株有214株，占41.8%，非产ESBLs菌株297株，占58.2%；喹诺酮类药物耐药菌株共?156株，其中ESBLs组耐药率51.4%（110/214），非产ESBLs组为15.5%（46/297）。结论：坪山坑梓地区Kp对喹诺酮类抗生素耐药率偏高，长期动态监测本区域耐喹诺酮类抗生素Kp，对本区域耐药谱的分析以及合理应用抗生素至关重要。 中国论文网 /6/viewhtm　　【关键词】 喹诺酮类抗生素； 肺炎克雷伯菌； 耐药性 　　Analysis of the Drug Susceptibility Results with the Quinolone Antibiotics Resistance of 156 Klebsiella Pneumoniae Strains/ZOU Xinyan，ZHONG Yanyun.//Medical Innovation of China，2018，15（06）：075-078 　　【Abstract】 Objective：To investigate and analyze the resistance of Klebsiella pneumoniae（Kp） to quinolone antibiotics in Pingshan Kengzi District.Method：A retrospective analysis of the number of non repetitive Kp resistant strains of quinolone antibiotics isolated from 2 659 samples of patients in our hospital from August 2014 to August 2017.Result：A total of 511 strains of Kp were isolated from 2 659 specimens，and the detection rate was 19.2%，among them，there were 214 strains of ESBLs strains， accounting for 41.8%，297 strains of non producing ESBLs strains，accounting for 58.2%.There were 156 strains of quinolone drug resistant strains，of which the drug resistance rate of ESBLs group was 51.4%（110/214），and non producing ESBLs group was 15.5%（46/297）.Conclusion：The resistance rate of Kp to quinolone antibiotics in pingshan kengzi area is high，the long-term dynamic monitoring of the region of Kp resistant to quinolone antibiotics，is essential for the analysis of the drug resistance spectrum in this region and the rational application of antibiotics. 　　【Key words】 Quinolone antibiotics； Klebsiella pneumoniae； Drug resistance 　　First-author’s address：Pingshan District Maternal and Child Health Hospital of Shenzhen，Shenzhen 518122，China 　　doi：10.3969/j.issn.1674-4985.2018.06.021 　　近年来，肺炎克雷伯菌（Klebsiella pneumoniae，Kp）仍是重要的条件致病菌和医院感染的常见病原菌[1-5]，随着临床分离率不断增多，全国细菌耐药监