198例消化系统神经内分泌肿瘤例分析.docVIP

198例消化系统神经内分泌肿瘤病例分析 　　摘 要 目的：探讨消化系统神经内分泌肿瘤（GEP-NETs）临床病理特征及其转移的影响因素。方法：回顾性分析198例GEP-NETs患者与GEP-NETs病理学类型及其转移的关系。结果：不同病理学类型GEP-NETs患者性别、发病年龄、淋巴结转移等情况的差异均具有统计学意义。单因素分析结果显示，性别、年龄、腹痛、肿瘤数目、肿瘤部位与GEP-NETs转移无明显相关性，而大便性状的改变、黑便或大便带血、肿瘤直径、病理学分级与GEP-NETs转移相关。logistics多因素回归分析显示，肿瘤直径与病理学分级是GEP-NETs发生转移的独立危险因素。结论：性别、发病年龄、淋巴结转移是影响GEP-NETs病理学类型的重要影响因素，肿瘤直径与病理学分级与GEP-NETs转移紧密相关。 中国论文网 /6/viewhtm　　关键词 消化系统神经内分泌肿瘤 病理学类型 转移 　　中图分类号：R736； R739.4 文献标识码：A 文章编号：1006-1533（2015）21-0045-03 　　Analysis of 198 cases of gastroenteropancreatic neuroendocrine tumors* 　　LIU Lijuan1**， YI Kewei2， WANG Beibei3， LI Guichun4（1. Department of Endocrinology， Xiangya Ping Kuang Cooperation Hospital， Pingxiang 337003， China； 2. Department of General Surgery， Xiangya Ping Kuang Cooperation Hospital， Pingxiang 337003， China； 3. Department of Gastroenterology， Xiangya Ping Kuang Cooperation Hospital， Pingxiang 337003， China； 4. Department of Pathology， The People’s Hospital of Yingtan City， Yingtan 337003， China） 　　ABSTRACT Objective： To discuss the clinical pathological features of gastroenteropancreatic neuroendocrine tumors（GEP-NETs） and the influence factors of its transformation. Methods： The clinical data of 198 cases of GEP-NETs patients as well as the relationship between the pathological types and the transformation of GEP-NETs were retrospectively analyzed. Results： The differences among the sex， the age at onset and the lymph node metastasis of GEP-NETs patients with different pathological types were statistically significant. Single factor analysis showed that sex， age， abdominal pain， tumor number， tumor location had no significant correlationwith GEP-NETs transformation， but the change of stool traits， black stool or bloody stool， tumor diameter and grading of pathology had significant relation to GEP-NETs transformation. Logistics multivariate regression analysis showed that tumor diameter and grading of pathology were the independent risk factors of GEP-NETs transformation. Conclusion