羊膜腔穿刺羊水细胞染色体检查用于高龄孕妇胎畸形预见性诊断分析.docVIP

羊膜腔穿刺羊水细胞染色体检查用于高龄孕妇胎儿畸形预见性诊断分析 　　[摘要] 目的 探讨高龄孕妇进行孕中期羊膜腔穿刺羊水细胞培养染色体核型分析，提高对胎儿畸形的预见性诊断分析结果。方法 随机选取该院2013年1月―2015年12月收治的714例高龄孕妇给予羊膜腔穿刺前的检查及超声诊断，行羊膜腔穿刺抽取羊水的孕妇，进行羊水细胞培养，制备染色体标本，分析高龄孕妇羊水胎儿细胞的染色体核型和胎儿染色体异常情况。 结果 该研究选取的 714例高龄孕妇中染色体异常的分类有21三体综合征、18三体综合征、性染色体异常和其它的染色体异常。有23例高龄孕妇的染色体出现异常，检出率为3.22%； 714例高龄孕妇中35～39岁占450例，发现胎儿染色体异常例数9例，检出率为2..00%为最低；44～46岁高龄孕妇占31例，发现胎儿染色体异常例数为3例，检出率为9.68%为最高。结论 在产前对高龄孕妇进行羊膜腔穿刺羊水细胞染色体培养可以有效的检测胎儿的染色体异常情况，有效的对高龄孕妇分娩畸形胎儿进行预见性的诊断，明显降低新生儿的缺陷率。 中国论文网 /6/viewhtm　　[关键词] 羊膜腔穿刺术；羊水细胞染色体核型；高龄孕妇；畸形儿；预见性诊断；染色体异常 　　[中图分类号] R246.3 [文献标识码] A [文章编号] 1674-0742（2016）09（a）-0011-03 　　[Abstract] Objective Discussion older pregnant women were second-trimester amniocentesis amniotic fluid cells of fetal malformation predictive diagnostic analysis of cultured karyotype analysis. Methods The study selected from our hospital in January 2013 to December 2015 in 714 cases of advanced maternal age to give pre amniocentesis examination and ultrasound diagnosis， underwent amniocentesis and amniotic fluid of pregnant women， the amniotic cell culture prepared chromosome specimen， analysis of women of advanced maternal age and fetal amniotic fluid cells stained color karyotype and fetal chromosomal abnormalities. Results The classification of chromosomal abnormalities in 714 cases of elderly women is 21， 18，， sex chromosome abnormalities and other chromosomal abnormalities. Have abnormal chromosomes in 23 cases of advanced maternal age， the detection rate was 3.22%； 714 cases of advanced maternal age 35 years old accounted for 450 cases， was found in 9 cases of fetal chromosomal abnormalities in the number of cases， detection rate for 2.00% was the lowest； 44～46 year old pregnant women accounted for 31 cases， found that 3 cases of fetal chromosomal abnormality cases detection 9.68% is the highest.Conclusion For older pregnant women at prenatal amniocentesis amniotic fluid cells cultured chromosomes can effectively detect fetal chromosomal abnormalities， effective deli