分娩方式对新生儿脐血HMGB1和HsCRP影响研究.docVIP

分娩方式对新生儿脐血HMGB1和HsCRP影响研究 　　【摘要】 目的 了解不同分娩方式对新生儿脐血高迁移率蛋白-1(HMGB1)和高敏CRP(Hs-CRP)水平的影响。方法 随机选择住院分娩、无妊娠合并症及并发症的产妇120例为研究对象,按分娩方式分为经阴道分娩组和择期剖宫产组,于分娩断脐后采集脐动脉血测定HMGB1和Hs-CRP含量。结果 阴道分娩组脐动脉血HMGB1和Hs-CRP含量明显高于剖宫产组,且存在显著性差异(t=8.36,7.29,P0.05);同时HMGB1和Hs-CRP之间存在显著正相关(r=0.63,P0.01)。结论 经阴道分娩时宫缩及产道挤压使胎儿HMGB1和Hs-CRP水平升高。 　　【关键词】 分娩方式;新生儿;脐血; HMGB1;高敏CRP(Hs-CRP) 　　 　　Study on influences of delivery patterns on HMGB1 and high-sensitive C-reactive protein in newborn cord blood 　　 　　LI Fang-ying,HUA Qian,BAN Kai-bin,et al.The Central People’s Hospital of Tengzhou, Shandong 277500,China 　　【Abstract】 Objective To investigate influences of delivery patterns on levels of high mobility group box-1 (HMGB1) and high-sensitive C-reactive protein(Hs-CRP) in cord blood of the newborn.Methods 120 parturients without any pregnancy associated diseases and complications and without fetal distress,neonatal malformation divided into normal delivery group and selected cesarean section group according to their delivery patterns.The umbilical arterial blood samples were taken immediately after cutting the umbilical cord from placenta and the levels of HMGB1 and Hs-CRP were detected.Results The level of HMGB1 in normal delivery group was higer than that selected cesarean section group,there was significant difference between the two groups(t=8.36,P0.05).The level of Hs-CRP in normal delivery group was higer than that selected cesarean section group,there was significant difference between the two groups(t=7.29,P0.05).There were a correlation between HMGB1 and Hs-CRP (r=0.63,P0.01).Conclusion The uterine contraction and obstetric canal squeeze on the fetus during normal vaginal delivery enable levels of HMGB1 and Hs-CRP in the cord blood of the newborn. 　　【Key words】Delivery pattern; The newborn; Cord blood; High mobility group box-1(HMGB1);High-sensitive C-reactive protein(Hs-CRP) 　　 　　高迁移率族蛋白-1(HMGB1)是近年发现的一种重要的晚期炎症介质,在炎症反应过程中表达升高较晚,维持时间较长,与组织损伤后修复、炎症反应等方面关系密切[1]。为探讨不同分娩方式与HMGB1水平的关系,我们检测了经阴道分娩、剖宫产分娩两种