肝脏脂肪变和冠脉疾病之间的相关性分析.pptxVIP

Relationship of hepatic steatosis severity and coronary artery disease characteristics assessed by coronary CT angiography 肝脏脂肪变和冠脉疾病之间的相关性分析 Abstract 目的：脂肪肝的严重程度和冠脉疾病特征之间的关系 Abstract 结论：尽管传统风因素对冠脉钙化和斑块形成具有极强的预测价值，脂肪肝的严重程度仍是阻塞性冠脉疾病独立的危险因素。冠脉CTA对脂肪肝患者危险分层可能具有潜在价值。 Methods 2028 patient ≤42HU obstructive disease high risk plaque extensive disease Logistic regression analysis was performed to study multivariate associations Patients with a segment involvement score4 排除：确诊CAD 严重运动伪影 实验室检查数据缺失 冠状动脉瘤术后 Methods Fig. 1 A radiologist placed 3 circular regions of interest (ROI) on the liver, drawn as large as possible, excluding the vessels on the calcium scoring image. The average CT number of the 3 measurements was used for further analysis. The CT number of each ROI was 47, 48 and 49 HU for this patient; therefore, an average of 48 HU was used for the analysis Results 男性和较胖者更容易出现严重脂肪变。糖尿病、高血压、血脂异常、吸烟均和肝脏脂肪变相关。饮酒、肝炎与肝脏脂肪变无关 Results Calcium scoring Severe steatosis was significantly associated with a higher calcium score (p = 0.02). Results Univariate analysis showed that G3 (p = 0.0003) and G4 (p = 0.03) were significantly associated with coronary calcium. Other parameters such as age, male sex, diabetes mellitus, hypertension, dyslipidemia, smoking and hepatitis virus infection were significantly associated with coronary calcium. The relationship between the severity of steatosis and coronary calcium was attenuated in the multivariate analysis, while age, male sex, diabetes mellitus, hypertension and dyslipidemia remained significant. Results Fig. 3 The frequency of patients with obstructive disease increased with the severity of hepatic steatosis. Obstructive disease was significantly more frequent in G2, G3 and G4 compared with G1 Stenosis analysis Results Univariate analysis demonstrated that steatosis severity was a significant parameter for obstructive disease (p0.0001) and G2, G3 and G4 were significantly associated with obstructive disease. Other parameters such a