抗生素课件（英文） Rational drug use of antibiotics in a Neonatal Intensive Care Unit.pptVIP

Rational drug use of antibiotics in a Neonatal Intensive Care Unit;Introduction;According to Quick et al (1997:422) RDU includes the following criteria: Correct drug Appropriate indication Appropriate dosage, administration, and duration of treatment; Appropriate patient Correct dispensing - this includes correct dispensing Patient’s adherence to treatment. ;Following recurrent outbreaks of neonatal Candida in the NICU prompted the management of the hospital to investigate the use of antibiotics in the NICU, to eliminate the likelihood that irrational use of antibiotics might have been one of the causes. ;Antibiotic protocol;;What antibiotics were used and how were they administered – “Correct drug” Of the 100 patients followed, 95 patients received intravenous antibiotics, of which 91 received antibiotics included in the units protocol Four patients received alternative antimicrobial therapy (e.g. tobramycin and ceftazidime) as required by their clinical conditions and sensitivity results.;Results;Results …;Number of antibiotics per patient The average number of antibiotics used per patient during the study period was 3.3. Figure 2 shows the numbers of patients who received different numbers of antibiotics.;; Duration of antibiotic use;Methicillin-resistant Staphylococcus aureus (MRSA);Implementation and improvements to practice;Results…; Antibiotics were used according to the ward protocol in the majority of cases. Deviations from the protocol were due to the fact that patients’ clinical condition and sensitivity results necessitated alternative antimicrobial treatment. ;As one of the doctors stated: ;Babies and their parents for participating in the study Doctors and nurses in the NICU for their cooperation Monika Zweygarth for assistance with the analysis of the data Medical Research Council for financial support Department of Pharmacy for logistical support