Vitamin B6 and B12 Intakes in Relation to Risk of 叶酸维生素B6和B12摄入量关系风险ppt课件.pptVIP

Folate, Vitamin B6, and B12 Intakes in Relation to Risk of Stroke Among Men  Ka He, MD;Anwar DMD; Eric B;. Rimm, ScD;Bernard A. Rosner, PhD; Meir J. Stempfer, MD;Walter C. Willett, MD; Alberto Ascherio, MDStroke. 2004;35:169-174Folate Intake and Risk of Stroke Among Wemen Wael K. Al-Delaimy, MD, PhD;Kathryn M. Rrxrode, MD, MPH; Frank B. HU, MD, PhD; Christine M. Albert, MD, MPH; Meir J. Stampfer, MD, DrPH;Walter C. Willett, MD, DrPH; John E. Manson, MD, DrTHStroke. 2004;35:1259-1263 ;Introduction;Folate (Folic acid);Homocysteine CVD Homocysteine level stroke (Brattstrom, et al.1992; ) Elevated homocysteine level Genetic defects (Brattstrom, et al.1998) Low intake of folate, vitamin B6 vitamin B12 (Verhoef, et al.1996);Folate metabolism;Study 1;Examining the relationship between prospectively intakes of folate and vitamin B6 and vitamin B12 and incidence of ischemic and hemorrhagic stroke in a large cohort of US men with an average 14 years of follow-up.;Subjects and Methods;The Health Professional Follow-up Study;;Outcome Assessment;Statistical Analyses;Statistical Analyses (cont.);Results;725 incident cases 455 ischemic stroke 125 hemorrhagic stroke 145 unknown type stroke;;; No significantly association between Dietary or supplemental folate and ischemic stroke No apparent jointly relation of alcohol consumption and folate intake to risk of ischemic or hemorragic stroke;Discussion;Inversely related to risk of ischemic stroke Folate intake (30% ) Vitamin B12 But not Vitamin B6 No significant associations with risk of hemorrhagic stroke were observed.;Other health-related factors Healthier lifestyle of higher folate intake Source of folate Other constituents of the supplement Inaccurate dietary assessment Inverse association between intakes of folate, vitamin B6, B12 and risk of CHD Repeated measurements Excluded participants wit