三七总皂苷对重症急性胰腺炎大鼠治疗作用的实验分析-experimental analysis of the therapeutic effect of panax notoginseng saponins on rats with severe acute pancreatitis.docxVIP
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三七总皂苷对重症急性胰腺炎大鼠治疗作用的实验分析-experimental analysis of the therapeutic effect of panax notoginseng saponins on rats with severe acute pancreatitis
group,thelevelofserumSODincreased(P0.05)andthelevelofMDAdecreased(P0.05)inPNStherapygroup.(5)TherateofbacterialtranslocationinPNStherapygroupwassignificantlydecreased.Underlightmicroscope,thevillistructuralintegrityoftheintestinalmucosainsham-operatedgroup,showingahighcolumnarepithelium,nointerstitialedemaandneutrophilinfiltration.InSAPgroup,interstitialedema,alargenumberofneutrophilinfiltrationwithlymphoidfollicularhyperplasia;intestinalvilliedemaandthicken;gobletcelldecreasewithdisorder;partoftheepithelialcellsnecrosisandfalling,thedamagesignificantlyinaprogressivemanner;ComparedtoSAPgroup,theintestinalmucosapathologicaldamagereducedinPNStherapygroup,manifestedasreducedinterstitialedemaandinflammatorycellinfiltration,intestinalvilliarrangedinorder,decreasedthenecrosisofepithelialcells.Conclusions:PNShadatherapeuticeffectonratswithSAPbyreducingthelevelsofwhitebloodcellcount、hematocrit、plasmafibrinogen、serumproinflammatorycytokinesTNF-α,IL-6,damagefactorDAOandbacterialtranslocationrate;increasinganti-inflammatorycytokinesIL-10,protectivefactorsSOD.Keywords:severeacutepanreatitis;panaxnotoginsengsaponins;inflammatoryfactor;oxygenradicals;bacterialtranslocation缩略语表(Listofabbreviations)一、常用单位dday天hhour小时minminute分钟mgmilligram毫克ggram克kgkilogram千克ulmicroliter微升lliter升mmmillimeter毫米mlmilliliter毫升二、专业术语APMAPSAPacutepancreatitismildacutepancreatitissevereacutepancreatitis急性胰腺炎轻型胰腺炎重症急性胰腺炎SIRSsystemicinflammatoryresponsesyndrome全身炎症反应综合征MODSIBFDOFRSODDAOTNF-αIL-6IL-10BTPNSELISEmultipleorgandysfunctionsyndromeintestinebarrierfunctinaldisturbanceoxygenfreeradicalssuperoxidedismutasemalondialdehydetumornecrosisfactor-αinterleukin-6interleukin-10bacterialtranslocationpanaxnotoginsengsaponinsEnzyme-LinkedImmunosorbentAssays多器官功能障碍综合征肠屏障功能障碍氧自由基超氧化物歧化酶丙二醛肿瘤坏死因子-α白细胞介素-6白细胞介素-10细菌移位三七总皂苷酶联免疫吸附试验学位论文原创性声明本论文是我个人在导师指导下进行的工作研究及取得的研究成果。论文中除了特别加以标注和致谢的地方外,不包含其他人或其它机构已经发表或撰写过的研究成果。对本文的研究做出贡献的个人和集体,均已在论文中以明确方式标明。本人完全意识到本声明的法律责任由本人承担。作者签名:日期:年月日学位论文使用授权声明本人授权汕头大学保存本学位论文的电子和纸质文档,允许论文被查阅和借阅;
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