沙漠干热环境下创伤失血性休克大鼠模型建立及干热环境对肝损伤影响-establishment of rat model of traumatic hemorrhagic shock in desert dry heat environment and effect of dry heat environment on liver injury.docxVIP

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沙漠干热环境下创伤失血性休克大鼠模型建立及干热环境对肝损伤影响-establishment of rat model of traumatic hemorrhagic shock in desert dry heat environment and effect of dry heat environment on liver injury.docx

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沙漠干热环境下创伤失血性休克大鼠模型建立及干热环境对肝损伤影响-establishment of rat model of traumatic hemorrhagic shock in desert dry heat environment and effect of dry heat environment on liver injury

II万方数据 II 万方数据 ABSTRACT Traumatic hemorrhagic shock(THS) is due to the body after violent action, the important viscera injury, severe bleeding, etc., make the effective circulating blood volume in patients with reduced, microcirculation perfusion inadequacy, and posttraumatic acute pain, fear, formed by many factors such as the comprehensive body of decompensated syndrome. Since half a century most of the local war and plateau, cold, hot, desert, island and other special geographical environment. Gobi and desert areas has obvious summer high temperature, large temperature difference between day and night, dry, hot, dry summer climate has increased the heat stress response of the body, when the body by trauma can induce the occurrence of shock, increase the difficulty of the subsequent rehydration therapy and mortality. This experiment at normal environment and dry heat environment of desert, the establishment of traumatic hemorrhagic shock model of rats and explore the dry heat environment of desert of traumatic hemorrhagic shock mechanism of liver damage, for laying a foundation for the further research of traumatic hemorrhagic shock. Objects: (1) To establishment a rats models of traumatic hemorrhagic shock under dry heat environment of desert.(2) To observe the liver pathologic histology, hepatocyte ultrastructure and the change of function in traumatic hemorrhagic shock rats under dry heat environment of desert, and explore the characteristic and rule of liver damage. Methods:(1) To control male SD rats reach traumatic hemorrhagic shock caused by wound and carotid artery auxiliary bloodletting under dry heat environment of desert, make the mean arterial pressure (MAP) of rats reached 35±5 mmHg level, establish a rats models of traumatic hemorrhagic shock under dry heat environment of desert.(2) A total of 140 male SD rats were equally divided randomly into traumatic hemorrhagic shock group under normal environment and traumatic hemorrhagic shock group under dry