乳腺癌患者化疗疲劳状况及影响因素的初步研究-a preliminary study on the status of chemotherapy fatigue and its influencing factors in breast cancer patients.docxVIP

thedatabySPSS11.5toexplorefactorsrelatedtoCRFinbreastcancerpatientsreceivingchemotherapy。Results：Thereare68patientscompletedalltherelevantdatacollection.Investigationsrevealedthat62%ofpatientsendurefatiguetheweekbeforechemotherapy.allpatientsendurevaryingdegreesoffatigueinthefirstweeksincechemotherapy,andtheincidenceofmoderateorseverefatiguewas54%.Tothethirdweeksincechemotherapyitisstill73%ofthepatientshadsymptomsoffatigue.Bymultiplelinarregressionanalysised,themostleveroffatiguewasassociatedwithpain(P=0.003)、courseofdisease(P=0.0429)、surgicaltreatment(P=0.0136)、whetheroranemia(P=0.0261)aswellasthenumberofpreviouschemotherapy(P=0.0004);theavrergeleveroffatiguewasassociatedwithpain(P=0.0117),duration(P=0.0015),numberofpreviouschemotherapyP=0.0092),andwhetherthechemotherapyregimencontainingdoxorubicin,andwhetherthepalliativechemotherapy).thenumberofchemotherapy(P=0.0092)、pain(P=0.0117)、courseofdisease(P=0.0015).thedurationoffatiguewasassociatedwiththenumberofchemotherapy(P0.001)、pain(P=0.0751)、courseofdisease(P0.0001)andwhethertpalliativechemotherapy(P=0.0713).Conclusion：Breastcancerpatientsendureahighincidenceoffatigue.Thereweresomefactorsthatcouldaffectcancer-relatedfatiguesuchaspain,courseofdisease,thenumberofchemotherapy,anaemia.Recommendshealthcareworkersshouldfocusonthemainfactorstointervenesoastoreducecancer-relatedfatigueinpatientswithlevel.Keyword:cancer-relatedfatigue;breastcancer;chemotherapy;FSI;associatellyfactors中英文缩略词表英文缩写英文全称中文名CRFCancer-relatedfatigue癌因性疲劳NCCNTheNationalCancerComprehesiveNetwork国家癌症综合网ICDInternationalClarificationofDisease国际疾病分类FSItheFatigueSymptomInventory疲劳症状量表NSEtheNumericalRatingScal数字量表KPSKarnofskyPerformanceStatus生活质量评分乳腺癌患者化疗疲劳状况及影响因素的初步研究1前言乳腺癌是危害妇女健康的主要恶性肿瘤之一，在欧美国家乳腺癌在女性恶性肿瘤中居首位，是导致妇女死亡的主要原因之一，平均每8名妇女就有一名患乳腺癌[1]。近年20年来，我国乳腺癌的发病率呈逐年上升趋势，尤其在京、津、沪等大城市，乳腺癌已居女性恶性肿瘤发病率之首，严重危害广大妇女的健康。自20世纪70年代Fisher提出的著名“乳腺癌一开始就是个全身性疾病”的观点，并且这一理论相继被北美洲和欧洲的两大前瞻性、多中心性的临床试验所证实[2]。由此以化疗为基础的综合治疗显得由为重要。化疗在乳腺癌的治疗中占有日益主要的地位，其最早是作为一种试验性的治疗方法，现在已成为大多数病人的标准的治疗