深度水解蛋白配方乳对早产儿早期胃肠道功能影响及机制探讨-effect and mechanism of deep hydrolyzed protein formula on gastrointestinal function in premature infants.docxVIP

Thehighestserumtotalbilirubin(TBIL)levelsofgroupIwerelowerthantheseofgroupII[(162.00±53.14)umol/Lvs(208.33±78.08)umol/L](P0.05),andthedurationofserumTBILreturningtonormalingroupIwereshortercomparedwithgroupII[(7.7±1.6)dvs(9.2±2.0)d](P0.01).Theserumtotalbileacid(TBA)levelsonthefourteenthdayofgroupIwerelowerthantheseofgroupII[(10.9±5.4)umol/Lvs(26.7±19.2)umol/L](P0.05).Motilin(MOT),gastrin(GAS)andamylin(AMY):BoththelevelsofMOTandGASintwogroupsshowedanupwardtrend,andthegroupItendedtobehigherthangroupII.ThelevelsofAMYontheseventhdayinbothgroupstendedtobehigherthantheseofthefirstday,thenshowedadeclineonthefourteenthday.ThelevelsofAMYontheseventhdayingroupItendedtobelower.Thesedifferenceswereallnotstatisticallysignificant(P0.05).Therewerenosignificantdifferenceswithregardtothetimeofrecoveringintobirthweight,thelevelsofserumalbumin(A),prealbumin(PA),bloodureanitrogen(BUN),calcium,phosphorus,andalkalinephosphatase(ALP)onthefirst,seventhandfourteenthdayintwogroups(P0.05),butthelevelsofALPonthefourteenthdayingroupItendedtobehigher.Conclusion:Theproteinhydrolysedformulamaybebeneficialtobilirubinmetabolismandmaycanreducecholestasisinpreterminfants.Thehydrolysedproteinformulashowsabeneficialtendencyonimprovingearlygastrointestinalfunctioninpreterminfantscomparedwithstandardpretermformula.3.Thelong-termeffectsofthisformulaonthegrowthanddevelopmentinpreterminfantsstillneedlongerfollow-up.Keywords:proteinhydrolysedformula;infant,preterm;gastrointestinalfunction;mechanism中英文缩略词表英文缩写英文全称中文全称NECENPNMEFNNSMOTGASAMYMCTELISALCTPABUNALPTBILTBAVLBWIELBWInecrotizingenterocolitisenteralnutritionparenteralnutritionmicroenteralfeedingnon-nutritivesuckingmotilingastrinamylinmediumchaintriglycerideenzyme-linkedimmunosorbentassaylong-chaintriglyceridesprealbuminbloodureanitrogenalkalinephosphatasetotalbilirubintotalbileacidsverylowbirthweightinfantextremelylowbirthweightinfant坏死性小肠结肠炎肠内营养肠外营养微量喂养非营养性吸吮胃动素胃泌素胰淀素中链甘油三脂酶联免疫吸附试验长链甘油三酯前白蛋白血尿素氮碱性磷酸酶总胆红素总胆汁酸极低出生体重儿超低出生体重儿独创性声明本人郑重声明，本学位论文是本人在导师指导下进行的研究工