十七种新型杂环化合物的电化学性质分析-analysis of electrochemical properties of 17 new heterocyclic compounds.docxVIP

摘要其中电子转移数三者均为n1≈1，n2≈1，n3≈1；电子转移系数A1(α1=0.60，α2=0.66，α3=0.40)，A2(α1=0.61，α2=0.67，α3=0.56)，A3(α1=0.64，α2=0.65，α3=0.57)；扩散系数DR分别为2.21×10-5cm2s-1(A1)，2.17×10-5cm2s-1(A2)，2.01×10-5cm2s-1(A3)；反应速率常数ks分别为0.21s-1(A1)，0.25s-1(A2)，0.34s-1(A3)。根据其电化学性质和动力学参数推断了其电极反应机理。在优化条件下用差示脉冲伏安法对三种样品进行定量分析，三者的还原峰电流与浓度在2.5×10-5~2×10-3mol/L范围内呈良好的线性关系。关键词：哌嗪；噻吩并嘧啶；电化学反应机理IIAbstractAseriesofnewderivativescontaining1,2,4-triazoleandpiperazineandderivativesofthieno[2,3-d]pyrimidinoneweresynthesizedbyourworkteam,andprovedtobewellantibacterialactivity.Inthisthesis,theelectrochemicalmechanismofthesecompoundswasstudiedtoprovideusefulinformationforthestudyoftheirpotentialpharmacologicalactivity.Themaincontentsareasfollows:Theelectrochemicalbehaviorsofsevenderivativescontaining[5-(4-chlorphenyl/fluorophenyl)]1,2,4-triazoleandpiperazinewereresearchedbycyclicvoltammetry(CV)andlinearsweepvoltammetry(LSV),andtheinfluenceofdifferentscanratesranging50~500mV/swerealsoinvestigated.Theelectrochemicalreactionsprovetobeirreversible,diffusion-controlledprocess.Theelectrontransfernumberwas2foreachcompound,whichwasobtainedbycontrolledpotentialelectrolysis.ThediffusioncoefficientsDRare1.66×10-4~8.87×10-4cm2s-1,calculatedbychronocoulometry(CC).thechargetransfercoefficientsαare0.20~0.33andelectrodereactionstandardrateconstantksare2.51×10-2~6.45×10-2s-1forc1-c7。Theelectrochemicalmechanismsofsevencompoundsarespeculatedasfollowing:theoxidationpeaksarecausedbypiperazine’soxidation.Theelectrochemicalbehaviorsofc1-c7arediscussedwiththeirstructures.Theelectrochemicalbehaviorsofderivativescontaining[5-phenyl/p-methylphenyl)]1,2,4-triazoleandpiperazineontheglassycarbonelectrodewerestudiedbyCVandLSV,andtheeffectsofdifferentscanratesranging50~500mV/swereresearched.Theresultsindicatedthattheelectrochemicalprocessofsevencompoundswereirreversibleanddiffusion-controlled.ThecontrolledpotentialelectrolysisandCCareusedtoobtaintheirelectrochemicalparameters:n≈2foreachcompound,αrangingfrom0.28to0.40,DRvaryingfrom1.93×10-4to4.49×10-4cm2