研究生信号转导课ppt课件.ppt

Cell Signal Transduction;What is cell signal transduction?;Small cell lung carcinoma ;Basic Profiles of Cell Signal Transduction;The response of a particular cell to a signal depends on the type of proteins it contains.;Signal; ;Seven major classes of membrane receptors;;Protein-Protein Interaction;Protein phosphorylation;Classical cell signaling pathway;Example 1: Integrin αIIbβ3 Mediates Dual-directions Signaling Transduction and Platelet Activation;Integrin αIIbβ3-Mediated Signaling and Hemostasis;Anti-platelet drugs;Example 2: Biology of PI3K/Akt signaling pathway;Gerrit van Meer, Dennis R. Voelker Gerald W. Feigenson. Membrane lipids: where they are and how they behave. Nature Reviews Molecular Cell Biology 9, 112-24;Lipid hydrolysis;Nature Reviews Drug Discovery 8, 627-644 (August 2009). Liu P et al;Nature Reviews Drug Discovery 8, 627-644 (August 2009). Liu P et al;Newton, A. C. J. Lipid Res. 2009;50:S266-S271;Receptors mediated Akt activation and its’ functions;Basic regulators of PI3K/Akt signaling pathway;PTEN, MMAC1, mutated in multiple advanced cancers 1;PI3-kinase is opposed by lipid phosphatase PTEN;;PI3K Signaling Inhibitors Tested;PI3K Signaling Inhibitors Tested for Cancer Chemotherapy;Insulin mediated PI3K Signaling and Diabetes;Platelets GPVI mediated PI3K/Akt Signaling and Arthritis;Platelet adhesive receptor GPVI mediated signaling;PROTEOMICS, Annual Review of Genomics and Human Genetics, Vol. 5: 267-293, 2004;GENOMICS;Metabonomic Network;CellDesigner is a structured diagram editor for drawing gene-regulatory and biochemical networks. Intuitive user-interface helps you to draw a diagram in rich graphical representation with your own design. ;Useful website;MAPK signaling ;Smad signaling ; Cell Signalling Biology - Michael J. Berridge - - 2009 ; Cell Signalling Biology - Michael J. Berridge - - 2009 ;NCBI（/）Signaling Transduction：;KEGG: Kyoto Encyclopedia of Genes and Genomes - GenomeNet;/pathwaycentral.php;Signaling pathway DIY;Any questions?