儿茶酚胺ppt课件.pptVIP

CATECHOLAMINES CATECHOL CATECHOLAMINE DOPAMINE (DIHYDROXYPHENYL- ETHYLAMINE) NOREPINEPHRINE (NORADRENALINE) EPINEPHRINE (ADRENALINE) CATECHOLAMINES NORADRENALINE – POSTGANGLIONIC FIBRES OF SYMPATHETIC NERVOUS SYSTEM (ADRENERGIC FIBRES) FOUND IN HIGHEST CONCENTRATION IN HYPOTHALAMUS AND CERTAIN ZONES OF LIMBIC SYSTEM. MOST NORADRENERGIC NEURONES ARISE IN LOCUS COERULEUS. INHIBITORY IN ACTION. ALSO IN ADRENAL MEDULLA. DOPAMINE – MAINLY IN CNS. FOUND IN BASAL GANGLIA ESP. CAUDATE NUCLEUS, NEOSTRIATUM, NUCLEUS ACCUMBENS, OLFACTORY TUBERCLE, CENTRAL NUCLEUS OF AMYGDALA, MEDIAN EMINENCE AND AND RESTRICTED FIELDS OF THE FRONTAL CORTEX. PREDOMINENT ACTION INHIBITORY ADRENALINE – CHROMAFFIN CELLS OF THE ADRENAL MEDULLA. IN CNS FOUND IN MEDULLARY RETICULAR FORMATION CONNECTING TO A FEW PONTINE AND DIENCEPHALIC NUCLEI. NORADRENALINE – DEFICIENCY – BEHAVIOURAL DEPRESSION - EXCESS – MANIA DOPAMINE – EXCESS – SCHIZZOPHRENIA PSYCHOSES - DEFICIENCY – PARKINSONS DISEASE HYPERTENSION -  CATECHOLAMINE  VASCULAR TONE  BP DOPAMINE (DIHYDROXYPHENYL- ETHYLAMINE) DOPAMINE-b-HYDROXYLASE (ASCORBIC ACID, O2, Cu2+ ) NOREPINEPHRINE (NORADRENALINE) PHENYLETHANOLAMINE-N- METHYL TRANSFERASE (S-ADENOSYLMETHIONINE) EPINEPHRINE (ADRENALINE) PHENYLALANINE TYROSINE DYHYDROXYPHENYLALANINE (DOPA) BIOSYNTHETIC PATHWAY PHENYLALANINE HYDROXYLASE (DIHYDROBIOPTERIN) TYROSINE HYDROXYLASE (TETRAHYDROPTERIDINE, O2, Fe 2+ ) 5 –8x10-5 M IN BLOOD DOPA DECARBOXYLASE L-AROMATIC AMINOACID DECARBOXYLASE (PYRIDOXAL PHOSPHATE) PHENYLETHANOLAMINE PHENYLETHYLAMINE DOPAMINE-b-HYDROXYLASE TYRAMINE OCTOPAMINE a-METHYLDOPA a-METHYLNOREPINEPHRINE FALSE NEUROTRANSMITTER Ser40 DIACYLGLYCEROL PROTEIN KINASE C ACase cAMPPK REGULATION OF TYROSINE HYDROXYLASE TETRAMER 59000 M.WT FEEDBACK INHIBITION BY CATECHOLAMINES N-TERMINAL REGULATORY DOMAIN Ser40 PHOSPHORYLATION BY cAMPPK OR PKC ON SERINE 40 DECREASES Km FOR PTERIDINE CO