糖尿病患者的心脏保护课件.ppt

ACEI;中国糖尿病及糖尿病增长的患病率;80%的2型糖尿病患者将合并CVD;The American Journal of Medicine (2006) 119, 591-599;J Am Coll Cardiol 2008;51:93–102;心脏损伤三联症;Atherosclerosis;血管闭塞, 炎症, 蛋白质紊乱;心血管死亡是糖尿病患者首要致死原因;调节肾素-血管紧张素-醛固酮系统的机制——改善胰岛素抵抗;脉管系统中ACEI的抗动脉粥样硬化作用;ADA/AHA共同推荐糖尿病患者CVD的一级预防措施;ADA糖尿病和CVD治疗指南中推荐的治疗措施;The American Journal of Medicine (2006) 119, 591-599;J Am Coll Cardiol 2008;51:93–102;糖尿病性心肌病(Diabetic Cardiomyopathy);;Sajad A. HAYAT?, Billal PATEL?, Rajdeep S Diabetic cardiomyopathy: mechanisms, diagnosis and treatment Clinical Science (2004) 107, 539–557;1 发病机制;Jarmila Machackova, Xueliang Liu, Anton Lukas Renin–angiotensin blockade attenuates cardiac myofibrillar remodelling in chronic diabetes Molecular and Cellular Biochemistry xxx: 1–8, 2004. ;J Am Coll Cardiol 2008;51:93–102;;;;;Journal of Cardiac Failure Vol. 12 No. 8 2006;Journal of Cardiac Failure Vol. 12 No. 8 2006 ;Am J Physiol Heart Circ Physiol 291:1489-1506, 2006. ;(Endocrine Reviews 25: 543–567, 2004);Diabetic cardiomyopathy: mechanisms, diagnosis and treatment Clinical Science (2004) 107, 539–557;3 治疗;Jarmila Machackova, Xueliang Liu, Anton Lukas Renin–angiotensin blockade attenuates cardiac myofibrillar remodelling in chronic diabetes Molecular and Cellular Biochemistry xxx: 1–8, 2004. ;Jarmila Machackova, Xueliang Liu, Anton LukasRenin–angiotensin blockade attenuates cardiac myofibrillar remodelling in chronic diabetesMolecular and Cellular Biochemistry xxx: 1–8, 2004.;Jarmila Machackova, Xueliang Liu, Anton LukasRenin–angiotensin blockade attenuates cardiac myofibrillar remodelling in chronic diabetesMolecular and Cellular Biochemistry xxx: 1–8, 2004.;接受哌道普利治疗的ZDF大鼠，其胰岛切片中增殖细胞核抗原染色阳性细胞数目增加;Phivos Symeonides a, Spyridon Koulouris b, Ekaterini Vratsista Both ramipril and telmisartan reverse indices of early diabetic cardiomyopathy: A comparative study Eur J Echocardiography (2007) 8, 480e486 ;ACEI的潜在作用机制——控制血糖;中位终点值;ACEI抗动脉粥样硬化的机制;PHYLLIS研究显示，ACEI可有效逆转颈动脉内膜中层厚度（IMT）达0.002mm/年;ACEI对糖???病患者的心血管保护作用具有确凿的循证证据;A