Dermatomyositis University of Colorado 硬皮病皮肌炎科罗拉多大学ppt课件.pptxVIP

SSc 101;outline;SSc clinical manifestations result from...;;Gu, S., et.al., Seminars in Arthritis, 2008;;Localized Scleroderma;Case 1: Puffy Hands;The next step would be: 1. Check for nailfold changes 2. Doppler study 3. Order ANA panel 4. Order ANCA 5. Skin biopsy 6. Pred 60mg IM x1 7. Tell her to take her husband’s viagra;Skin: Raynaud’s;Raynaud’s;Nailfold Capillaroscopy;Images in Raynaud’s;Treatment of Raynaud’s;Severe Digital Ischemia;Early Skin Changes in Diffuse SSc;Late Skin Changes;Other skin changes ;Case 2;Scleroderma Renal Crisis;Renal Involvement in diffuse scleroderma;Syndromes in Systemic Sclerosis;Other Organ Involvement;Gastrointestinal Involvement;Lung Involvement;Active ILD in SSc likely to be NSIP;Cardiac Involvement;Diffuse disease, assessment over time;Face;Clinical Meaningfulness of Change in MRSS;lcSSc (limited cutaneous systemic sclerosis)Calcinosis, Raynaud’s, Esophageal dysmotility,Sclerodactly, Telangiectasia;Case 3;1. Homogeneous 2. Nucleolar 3. Peripheral 4. Centromere 5. Speckled;Classification of Systemic Sclerosis and Organ Involvement;homogenous (diffuse);Antibodies as clues to phenotype, organ involvement, prognosis;Predominant Features Associated with Scleroderma-Specific Autoantibodies;Survival according to antibody;Env/Occup Genetics;Epidemiology;Treatment overview;“No drug has been shown to be completely worthless until tried in Scleroderma” –Eric Bywaters;Scleroderma 3K/5K walk;References;Organ Involvement and Survival;Therapy of localized scleroderma