止血凝血机制课件.ppt

止血、凝血机制;正常止血机制;Normal hemostasis（止血）;;;+;Platelets adhere to VWF bound to sub-endothelium collagen;The platelet is activated and fibrinogen and other adhesive proteins engage with GpIIb/IIIa ;Tissue factor initiates thrombin generation. Thrombin activates factors V and VIII;Thrombin converts fibrinogen to fibrin;Fibrin acts as a cofactor for thrombin-dependent FXIII activation. ;+;Thrombin binds to GpIba, cleaves PAR and GpV (not shown) and further activates platelets;;Thrombin bound to GpIba activates FXI, leading to further thrombin generation ;+;Thrombin proteolytically inactivates AD