全自动宫颈癌细胞筛查系统的分析与设计-analysis and design of automatic cervical cancer cell screening system.docxVIP

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全自动宫颈癌细胞筛查系统的分析与设计-analysis and design of automatic cervical cancer cell screening system.docx

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全自动宫颈癌细胞筛查系统的分析与设计-analysis and design of automatic cervical cancer cell screening system

南昌航空大学硕士学位南昌航空大学硕士学位论文摘要 I II Abstract Medical experts and patients pay more and more attention to cervical cancer which is one of the most common gynecologic malignancies in the world. Cervical cytology testing which is an early diagnostic method can significantly reduce the morbidity and mortality. However, not all women could receive cervical cytology testing. And because of their subjective consciousness, fatigue and effectiveness, pathologists with long-time working under microscope would easily cause highly false negative rate. In order to improve the efficiency, reduce the false negative rate, and increase the screening rates, the research of computer-assisted screening for cervical cancer emerged as the times require. The very representative device are AutoPap, PapNet and ThinPrep. But the cost of this equipment is so high that it is hard to achieve global diffusion. So the contents of this paper are about computer-assisted recognition technology. And a kind of fully automatic medical instrument was designed and applied to the clinical trial, which would auxiliarily diagnose the cervical cancer. During the period of clinical trial, this system helped the pathologist detect a missed positive sample. This paper introduce automatic cervical cancer cell screening system on four parts, including system design, image preprocessing, segmentation and recognition of cervical cell nucleus. 1) The system design include sample loading, image acquisition, image processing and analysis. 2) The image pre-processing comprise image focusing and preprocessing. On the focusing aspect, the focus evaluation curve is bimodal shaped due to the impurity layer of coverslip, which is easily misread as focal plane using the common focusing algorithm. However, the accurate rate of the refined image focusing algorithm could reach to 100%, which would overcome this kind of misjudge. 3) In the image segmentation part, this paper proposed a new image segmentation algo