辛伐他汀调控小胶质细胞极化状态的实验分析-experimental analysis of simvastatin regulating microglia polarization state.docxVIP

I万方数据 I 万方数据 目 录 中 文 摘 要 ··························································································· 1 英 文 摘 要 ··························································································· 4 英 文 缩 略 词 表 ·················································································· 9 前 言 ··································································································· 11 正 文 第一部分 BV2 小胶质细胞的经典激活及替代激活 15 1 材料与方法 ·················································································· 15 2 结果 ··························································································· 22 3 讨论 ··························································································· 27 4 参考文献 ····················································································· 29 第二部分 Notch 信号通路对 BV2 小胶质细胞经典及替代激活途径的调控········· 31 1 材料与方法 ·················································································· 32 2 结果 ··························································································· 39 3 讨论 ··························································································· 42 4 参考文献 ····················································································· 45 第三部分 辛伐他汀对 Notch 信号通路的影响 ············································· 48 1 材料与方法 ·················································································· 49 2 结果 ··························································································· 57 3 讨论 ··························································································· 59 4 参考文献 ····················································································· 61 第四部分 辛伐他汀对 BV2 小胶质细胞极化状态的调控 ································ 63 1 材料与方法 ·················································································· 64 2 结果 ·················································································