膝关节软骨损伤的尿ctx-ⅱ和定量磁共振成像的分析-analysis of urine ctx - ⅱ and quantitative magnetic resonance imaging in knee cartilage injury.docxVIP

股骨髁各软骨亚区间有显著差异（P=0.009），股骨内侧髁软骨T?值（46.14±4.19ms）股骨外侧髁软骨T?值（42.64±4.76ms），P=0.001；胫骨平台各软骨亚区之间T?值无明显差异性（P=0.5740.05）；胫骨内侧平台软骨T?值（38.55±4.16ms）和胫骨外侧平台软骨T?值（36.76±3.72ms）无明显差异性（P=0.0940.05）。结论：(1)uCTX-Ⅱ水平和T?值能够反应关节软骨损伤的程度，uCTX-Ⅱ水平和T?值增高提示关节软骨损伤程度加重；重度损伤的软骨会变薄，与关节镜下的结果一致；(2)uCTX-Ⅱ水平、ThC和T?值之间有相关性，间接证明T?值能够反应软骨中胶原蛋白的退变。(3)健康者胫股关节不同软骨亚区的ThC和T?值各有所不同。关键词：关节软骨软骨厚度定量磁共振成像uCTX-ⅡT?mappingAbstractObjective:(1)TosummarythecharacteristicsofuCTX-Ⅱlevels,ThCsandT?valuesinthehealthsandpatientswithmildandseverecartilageinjury;(2)TocomparethedifferencesofuCTX-Ⅱlevels,ThCsandT?valuesamonghealthyandpatientswithmildandseverecartilageinjury,andtoassesstheirvaluesincartilagedamage;(3)ToexploretherelationshipbetweencartilageBMandqMRI.MaterialsandMethods:(1)47leftorrighttibiofemoraljointsfrom2013.9to2013.12,includingmale22cases,female25cases,averageageis46.7yearsold,35caseswithtibiofemoralarticularcartilageinjurywerediagnosedbyarthroscopic,and12caseswerehealthyascontrolgroup;(2)Tibiofemoralarticularcartilagewasdividedinto10subregions:MFa,MFc,MFp,LFa,LFc,LFp,MTa,MTp,LTaandLTp.ThedegreeofeachsubregioncartilageinjurywasaccessedbyusingimprovedOuterbridge’scoresystemunderarthroscopy,allthesubjectsweredividedinto3groups:score=0ashealthygroup(Hgroup)(n=12),score10pointsasmildinjurygroup(S1group)(n=23),score≥10pointsassevereinjurygroup(S2group)(n=12);(3)uCTX-ⅡlevelsofmorningurinecollectedinaweekbeforesurgeryweredetectedwithELISA;(4)sagittal3D-WATScsequenceandT?mappingsequencewereperformedforeachoneonPHILIPS3.0TMRIinaweekbeforesurgery,imagesweretransferredtoEWSworkstationformeasuringtheThCandT?values;(5)alldatumwillbeanalyzedwithSPSS19.0.Results：(1)TheT?valuesofHgroup,S1groupandS2groupwere41.70±2.16msvalue,48.16±2.73msand57.15±4.87ms;theThCsofHgroup,S1groupandS2groupwere2.43±0.21mm,2.38±0.20mmand1.89±0.21mm;theuCTX-ⅡlevelsofHgroups,S1groupandS2groupwere133.48±26.80pg/ml,410.88±139.01pg/mland598.61±218.23pg/ml;(2)TheT?valuesweresignificantlydifferentamongHgroup,S1groupandS2group(P=0.000),HgroupS1groupS