AMI患者hsCRP水平及外周血淋巴细胞计数与心功能关系临床研究.docVIP

AMI患者hsCRP水平及外周血淋巴细胞计数与心功能关系临床研究 　　【摘要】 目的 通过对hs-CRP与外周淋巴细胞计数在急性心肌梗死(AMI) 发作期间的监测,探讨与心功能的相互关系。 方法 随机选取健康志愿者32例(对照组)和急性心肌梗死患者106例,连续3 d测定其空腹血清hs-CRP浓度及血常规,取其平均值为测定值,并用彩色多普勒分别检测出他们的左室射血分数(LVEF)。结果 急性心肌梗死(AMI)组血清hs-CRP明显升高,外周血淋巴细胞计数明显降低,两组比较差异有统计学意义(P0.05);并且血清hs-CRP水平与心功能(LVEF)呈负相关(P0.05),外周血淋巴细胞计数水平与心功能(LVEF)正相关(P0.05)。结论 急性心肌梗死患者血清hs-CRP水平明显升高,与心功能(LVEF)呈负相关,而外周血淋巴细胞计数则正相关。 　　【关键词】 急性心肌梗死;高敏C反应蛋白;外周血淋巴细胞计数 ;心功能 　　 　　Correlation of hs-CRP and Peripheral blood lymphocyte count with cardiac function in patients with acute myocardial infa 　　 　　ZENG Yuan-jie.ShanTou ChaoYan Da-feng Hospital,Shantou 515100,China 　　 　　【Abstract】 Objective To examine the correlation of the High sensitive-CRP ,(hs-CRP) levels and peripheral blood lymphocyte count with Cardiac function.Methods The serum levels of hs-CRP and peripheral blood lymphocyte count were detected in 32 healthy adults and 106 patients with AMI.The datas of remodeling and cardiac function (LVEF) were measured by echocardiography in all persons.Results Compared with control group,AMI patients had high serum levels of hs-CRP(P0.05).The lower LVEF class,the higher the levels of hs-CRP and the lower the peripheral blood lymphocyte count (P0.05).The levels of hs-CRP were negative corelation with cardiac function (LVEF) (P0.05), but peripheral blood lymphocyte count were positive(P0.05).Conclusion The levels of serum hs-CRP significantly increased in the AMI patients.Th e levels of hs-CRP are negative correlation with cardiac function (LVEF), but peripheral blood lymphocyte count were positive. 　　【Key words】 Acute myocardial infarction;hs-CRP;Cardiac function 　　 　　急性心肌梗死(acutemyocardial infarclion ,AMI)是一种高危疾病,近年来不但发病率增加,症状亦趋于不典型,死亡率高,为了降低死亡率,临床上使用很多方法来寻找预测其预后敏感指标。hs-CRP和淋巴细胞计数就是其中两个指标,且易于基层推广,故有极高应用价值。高敏C 反应蛋白(hs-CRP) 是机体非特异性炎性反应的敏感标志物之一,已有研究表明与冠心病存在一定关系,同时,AMI在早期白细胞应激性升高与淋巴细胞计数降低十分常见,本文通过hs-CRP与淋巴细胞计数两个指标在急性心肌梗死(AMI) 发作期间改变与心功能的相互关系,以探讨与AMI预后的相关性。 　　1 资料与方法 　　1.1 一般资料 选择2008年4月至2010年2月确诊AMI 的住院患者106例(A组)作为研究对象