2型糖尿病患者干眼与糖尿病视网膜病变相关性研究.docVIP

2型糖尿病患者干眼与糖尿病视网膜病变相关性研究 　　[摘要] 目的 探讨2型糖尿病患者干眼的患病率及其与糖尿病视网膜病变的相关性。 方法 对363例住院2型糖尿病患者通过询问和病历回顾获得所有患者的临床资料，包括性别、年龄、病程、糖基化血红蛋白和其他疾病史，同时进行干眼的相关检查和对糖尿病视网膜病变进行分级。 结果 363例2型糖尿病患者中干眼97例，干眼总患病率为26.7%。2型糖尿病患者干眼的患病率和性别无关，与病程相关。无糖尿病视网膜病变（no diabetic retinopathy，NDR）组、非增生性糖尿病视网膜病变（non-proliferative diabetic retinopathy，NPDR）组及增生性糖尿病视网膜病变（proliferative diabetic retinopathy，PDR）组的干眼患病率分别为15.6%、28.7%及46.7%，三组间两两比较差异均有统计学意义（P7%组干眼的患病率为34.8%，两组比较差异有统计学意义（P0.05）。 结论 2型糖尿病患者干眼的患病率和糖尿病视网膜病变的严重程度、HbA1c相关，PDR及高HbA1c患者更易发生干眼。 　　[关键词] 干眼；糖尿病视网膜病变；糖基化血红蛋白；2型糖尿病 　　[中图分类号] R587.2；R774.1 [文献标识码] B [文章编号] 1673-9701（2016）35-0068-03 　　Study on the correlation between dry eye and diabetic retinopathy in the patients with type 2 diabetes 　　ZHUANG Guobin WU Xiaomin ZHU Meihong WANG Xiuchun ZHENG Tongmei 　　Department of Ophthalmology， Quanzhou First Hospital， Fujian Medical University， Quanzhou 362000， China 　　[Abstract] Objective To study the correlation between the prevalence of dry eye and diabetic retinopathy in patients with type 2 diabetes mellitus. Methods The clinical data of 363 inpatients with type 2 diabetes mellitus were collected by questionnaires and medical records， including gender， age， duration， glycosylated hemoglobin and other diseases. At the same time， dry eye-related examination and classification of diabetic retinopathy were carried out. Results Among the 363 patients with type 2 diabetes mellitus， 97 patients were with dry eyes and the total prevalence rate of dry eye was 26.7%. The prevalence rate of dry eye in the patients with type 2 diabetes mellitus was not associated with gender and was associated with disease duration. The prevalence of dry eye in no diabetic retinopathy（NDR） group， non-proliferative diabetic retinopathy（NPDR） group and proliferative diabetic retinopathy（PDR） group was 15.6%， 28.7% and 46.7% respectively. Any of two groups among the three groups were compared， and the differences were statistically significant（P 7% group. There was statistical si